Is HC Orange No. 6 safe in cosmetics?
HC Orange No. 6 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Orange No. 6
INCI: HC ORANGE NO. 6
HC Orange No. 6 (CAS 1449653-83-1) is a cosmetic cosmetic ingredient functioning as Hair dyeing (direct/semi-permanent dye). Reported NOAEL =10 mg/kg bw in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted, max 0.5%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1449653-83-1 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing (direct/semi-permanent dye)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[4-[(E)-2-[1-[2-[2-[2-[(E)-2-[4-[bis(2-hydroxyethyl)amino]phenyl]ethenyl]pyridin-1-ium-1-yl]ethyldisulfanyl]ethyl]pyridin-1-ium-2-yl]ethenyl]-N-(2-hydroxyethyl)anilino]ethanol;methanesulfonate
InChIKey
LOGITAXZYWCDHX-UHFFFAOYSA-L
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
Falls under the coal tar hair dye exemption (FD\&C Act §601(a)); permitted with appropriate caution labeling and patch test instructions; not subject to batch certification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Orange No. 6.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Orange No. 6. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | - | - | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/d | oral | rat | developmental toxicity | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: As from 3 June 2021: 0,5 %.
BRIN Brazil/India Cosmetics
India: Restricted · max As from 3 June 2021: 0,5 %
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.039% | - | - | SCCS/0201 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for HC Orange No. 6.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Orange No. 6 by CAS number or substance name.
Studies
28
Lowest NOAEL
10
Highest NOAEL
300
Units vary across source rows: mg/kg bw/day, mg/kg/day, mg/kg bw
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.039% | - | - |
Frequently Asked Questions
Is HC Orange No. 6 allowed in the EU?
HC Orange No. 6 EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Orange No. 6 do in cosmetics?
HC Orange No. 6 functions as: Hair dyeing (direct/semi-permanent dye). It is classified as a cosmetic ingredient in our database. CAS number: 1449653-83-1.
What is the NOAEL for HC Orange No. 6?
The NOAEL (No Observed Adverse Effect Level) for HC Orange No. 6 is =10 mg/kg bw based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Compliance Tools
Check HC Orange No. 6 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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