What is the NOAEL for 2,3,5-Trimethylpyrazine?
2,3,5-Trimethylpyrazine has 6 NOAEL studies in the database. The lowest reported value is Q8PR0W8TIT UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2,3,5-Trimethylpyrazine
Also known as: BRN 0002423, EINECS 238-712-0, FEMA No. 3244, 2,3,5-Trimethyl pyrazine, UNII-Q8PR0W8TIT
CAS 14667-55-1
2,3,5-Trimethylpyrazine (CAS 14667-55-1) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
2,3,5-Trimethylpyrazine
CAS Number
14667-55-1
DTXSID
DTXSID1047075
Molecular Formula
C7H10N2
InChI Key
IAEGWXHKWJGQAZ-UHFFFAOYSA-N
Monoisotopic Mass
122.084398
Synonyms
BRN 0002423EINECS 238-712-0FEMA No. 32442,3,5-Trimethyl pyrazineUNII-Q8PR0W8TIT
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| Q8PR0W8TIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q8PR0W8TIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q8PR0W8TIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q8PR0W8TIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =806 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 18 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 6 of 6 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL320146
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,3,5-Trimethylpyrazine?
2,3,5-Trimethylpyrazine appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2,3,5-Trimethylpyrazine used in cosmetics?
Yes, 2,3,5-Trimethylpyrazine is also indexed as a cosmetic ingredient under the name Trimethylpyrazine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,3,5-Trimethylpyrazine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,3,5-Trimethylpyrazine used outside industrial chemicals?
2,3,5-Trimethylpyrazine also appears in cosmetics, pharmaceutical, cannabis databases.