Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Trimethylpyrazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 18 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 18 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Fragrance ingredient subject to RIFM monitoring; genotoxicity, repeated dose, and reproductive toxicity endpoints all evaluated with no concerns identified
Regulatory Flags
Frequently Asked Questions
Is Trimethylpyrazine safe in cosmetics?
Fragrance ingredient subject to RIFM monitoring; genotoxicity, repeated dose, and reproductive toxicity endpoints all evaluated with no concerns identified The EU classifies Trimethylpyrazine as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Trimethylpyrazine allowed in the EU?
Trimethylpyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylpyrazine do in cosmetics?
Trimethylpyrazine functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 14667-55-1.
What is the Margin of Safety for Trimethylpyrazine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trimethylpyrazine?
The NOAEL (No Observed Adverse Effect Level) for Trimethylpyrazine is 18 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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