Also known as: Oxyquinoline, 8-Quinolinol, 5-21-03-00252, BRN 0114512, Caswell No. 719 (+14 more)
CAS 148-24-3
8-Hydroxyquinoline (CAS 148-24-3) is a chemical substance with GHS signal word Danger; key hazard signal: H360D; H301; H318; H317; H400; H410. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
8-Hydroxyquinoline is classified GHS Danger (H360D, H301, H318, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics at max II/395.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 13, Sup 7 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 | H360D; H301; H318; H317; H400; H410 | GHS08; GHS06; GHS05; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Raw materials | Air Water INC | Air Water INC |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| banned; Europe; Personal care | European Commission | CosIng |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.05 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.05 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.05 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.05 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 69.68 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =3.29 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5UTX5635HP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5UTX5635HP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5UTX5635HP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5UTX5635HP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.1184 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >1.21 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =73 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =89 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =89 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =150 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =150 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =217 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =217 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =349 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =349 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =600 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =600 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =900 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =900 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =300 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =240 | ppm | LOEL | oral | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =75 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =75 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =450 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB_ToxRefDB |
| =450 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2.78 | mg/kg bw/day | NOAEL | oral | Japanese Quail | ToxValDB_EFSA |
| =2.78 | mg/kg bw/day | NOAEL | - | Japanese quail | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =5 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_EFSA |
| =5 | mg/kg bw/day | NOAEL | - | Rabbit | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =73 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =73 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =73.3 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =73.3 | mg/kg bw | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =97.7 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =97.7 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
Showing 50 of 53 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Quinolin-8-ol | 205-711-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →8-Hydroxyquinoline (CAS 148-24-3) is classified under EU CLP Annex VI as Repr. 1B; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H360D; H301; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
8-Hydroxyquinoline has 53 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
8-Hydroxyquinoline appears on 6 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, active_ingredient; Europe; Pesticides, Raw materials, and 3 more. Source: EPA CPDat.
8-Hydroxyquinoline is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, 8-Hydroxyquinoline is also indexed as a cosmetic ingredient under the name OXYQUINOLINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
8-Hydroxyquinoline is classified GHS Danger (H360D, H301, H318, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics at max II/395.
8-Hydroxyquinoline also appears in cosmetics, pharmaceutical, cannabis databases.