Danger GHS08GHS06GHS05GHS09 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

8-Hydroxyquinoline

Also known as: Oxyquinoline, 8-Quinolinol, 5-21-03-00252, BRN 0114512, Caswell No. 719 (+14 more)

CAS 148-24-3

8-Hydroxyquinoline (CAS 148-24-3) is a chemical substance with GHS signal word Danger; key hazard signal: H360D; H301; H318; H317; H400; H410. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.

View cosmetic safety profile for OXYQUINOLINE →

SOURCE NOAEL studies
NOAEL studies
46
SOURCE Chemical inventory jurisdictions
Regulatory lists
7
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields
Name
8-Hydroxyquinoline
CAS Number
148-24-3
Molecular Formula
C9H7NO
InChI Key
MCJGNVYPOGVAJF-UHFFFAOYSA-N
Monoisotopic Mass
145.052764
Synonyms
Oxyquinoline8-Quinolinol5-21-03-00252BRN 0114512Caswell No. 719EINECS 205-711-1EPA Pesticide Chemical Code 059803FennosanFennosan HF-15HydroxybenzopyridineNCI-C55298Oxybenzopyridine

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable198713, Sup 7

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Repr. 1B; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1H360D; H301; H318; H317; H400; H410GHS08; GHS06; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Stabilizing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records
ListKeywordSource
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
Raw materialsAir Water INCAir Water INC
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
banned; Europe; Personal careEuropean CommissionCosIng
Canada; pharmaceuticalDrugBankDrugBank
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 46 of 46 studies
ValueUnitEndpointRouteSpeciesSource
=0.05mg/kg bw/dayADI-ConsumersEFSA
=0.05mg/kg bwARfD-ConsumersEFSA
69.68uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
=3.29mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
5UTX5635HPUNIIFDA UNII substance identifier--openFDA substances
0.1184fractionFu-HumanNTP ICE adme parameters
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP ICE cancer
>1.21mg/LLC50Inhalation-NTP ICE acute inhalation
=1200mg/kg bwLD50oralRatNTP ICE acute oral
=73mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=89mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=89mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=150mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=150mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=217mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=217mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=349mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=349mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=600mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=600mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=900mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=900mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=300mg/kg bw/dayLOAELoralRatToxValDB ToxRefDB
=300mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=240ppmLOELoralRatToxValDB ECOTOX
0unitlessModel Score--NTP ICE endocrine
>0mg/kg bw/dayNELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=75mg/kg bw/dayNELoralRatToxValDB ToxRefDB
=75mg/kg bw/dayNELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=450mg/kg bw/dayNELoralMouseToxValDB ToxRefDB
=450mg/kg bw/dayNELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=2.78mg/kg bw/dayNOAELoralJapanese QuailEFSA
=2.78mg/kg bw/dayNOAEL-Japanese quailEFSA
=5mg/kg bw/dayNOAELoralRabbitEFSA
=5mg/kg bw/dayNOAEL-RabbitEFSA
=73mg/kg bw/dayNOAELoralRatEFSA
=73mg/kg bw/dayNOAEL-RatEFSA
=73.3mg/kg bw/dayNOAELoralRatEFSA
=73.3mg/kg bwNOAEL-RatEFSA
=97.7mg/kg bw/dayNOAELoralRatEFSA
=97.7mg/kg bw/dayNOAELoral: unspecifiedRatEFSA
=100mg/kg bw/dayNOELoralRatToxValDB HESS
=250mg/kg bw/dayNOELoralMouseToxValDB ECOTOX
=600mg/kg bw/dayNOELoralRatToxValDB ECOTOX
3000ppmTop doseDosed feedMouseNTP ICE cancer

Showing 46 of 46 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredQuinolin-8-ol205-711-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
II/395
Category
Preservatives
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed OXYQUINOLINE
ChEMBL Phase
-1
Adverse Events
30
Bioactivity
16
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 8-Hydroxyquinoline?

8-Hydroxyquinoline (CAS 148-24-3) is classified under EU CLP Annex VI as Repr. 1B; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H360D; H301; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 8-Hydroxyquinoline?

8-Hydroxyquinoline has 46 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include 8-Hydroxyquinoline?

8-Hydroxyquinoline appears on 6 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, active_ingredient; Europe; Pesticides, Raw materials, and 3 more. Source: EPA CPDat.

Is 8-Hydroxyquinoline a carcinogen according to IARC?

8-Hydroxyquinoline is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 8-Hydroxyquinoline used in cosmetics?

Yes, 8-Hydroxyquinoline is also indexed as a cosmetic ingredient under the name OXYQUINOLINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 8-Hydroxyquinoline come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 8-Hydroxyquinoline have different safety status in cosmetics vs industrial chemicals?

8-Hydroxyquinoline is classified GHS Danger (H360D, H301, H318, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics at max II/395.

Is 8-Hydroxyquinoline used outside industrial chemicals?

8-Hydroxyquinoline also appears in cosmetics, pharmaceutical, cannabis databases.