Is OXYQUINOLINE safe in cosmetics?
OXYQUINOLINE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: prohibited. This ingredient has been reviewed by cir.
OXYQUINOLINE
Also known as: 8-Quinolinol, 5-21-03-00252, BRN 0114512, Caswell No. 719, EINECS 205-711-1 (+13 more)
OXYQUINOLINE (CAS 148-24-3) is a cosmetic cosmetic ingredient functioning as Antimicrobial, Chelating. EU Regulation 1223/2009 status: restricted, max II/395; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 148-24-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OXYQUINOLINE is classified GHS Danger (H301, H302, H317, H318, H360, H400, H410, H311) in the chemicals database but is restricted in EU cosmetics at max II/395.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial, Chelating
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
quinolin-8-ol
InChIKey
MCJGNVYPOGVAJF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/395
US US Status
prohibited
US Notes
Not specifically banned by FDA for cosmetics, but the CIR (Cosmetic Ingredient Review) has assessed it. Its use has largely been abandoned in the US market due to safety concerns
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
6 December 2005
Verdict: unknown
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
13, Sup 7
Evaluation Year
1987
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardAcute ToxicityCorrosiveEnvironmental Hazard
Hazard Class and Category
Repr. 1B; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H360D
- H301 Toxic if swallowed
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 1; M = 1
Inserted via ATP: ATP10
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics except uses in Annex B |
| ASEAN | restricted | 0.3% (rinse-off hair); 0.03% (non-rinse hair) | Hair care products |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
8-Hydroxyquinoline | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 13: (1977) Some Miscellaneous Pharmaceutical Substances | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
8-Hydroxyquinoline | TR-276: Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CASRN 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1985 ) | 03/23/84 | No Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of these studies, there was no evidence of carcinogenicity for male and female F344/N rats or for male and female B6C3F1 mice given 8-hydroxy
Source: NTP Technical Reports
Evidence for Carcinogenicity
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Stabilizing agent
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for OXYQUINOLINE.
Regulatory Flags
cosing-sourced
eu-restricted
preservative
needs-enrichment
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
8-Quinolinol
5-21-03-00252
BRN 0114512
Caswell No. 719
EINECS 205-711-1
EPA Pesticide Chemical Code 059803
Fennosan
Fennosan HF-15
Hydroxybenzopyridine
NCI-C55298
Oxybenzopyridine
USAF EK-794
o-Oxychinolin
UNII-5UTX5635HP
8-Chinolinol
8-Hydroxy-chinolin
8-OQ
8-Quinol
Chemical Function
Stabilizing agent
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
active_ingredient; Europe; Pesticides
Raw materials
Canada; consumer_product; Substances in Products - Canada (4/2014)
banned; Europe; Personal care
Canada; pharmaceutical
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OXYQUINOLINE
ChEMBL ID
CHEMBL310555
Max Phase
-1
Adverse Event Associations
30
Frequently Asked Questions
Is OXYQUINOLINE allowed in the EU?
OXYQUINOLINE EU regulatory status: restricted. Maximum allowed concentration: II/395. This is based on EU Regulation 1223/2009 and its amendments.
What does OXYQUINOLINE do in cosmetics?
OXYQUINOLINE functions as: Antimicrobial, Chelating. It is classified as a cosmetic ingredient in our database. CAS number: 148-24-3.
Is OXYQUINOLINE used outside cosmetics?
OXYQUINOLINE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OXYQUINOLINE have different safety status in cosmetics vs industrial chemicals?
OXYQUINOLINE is classified GHS Danger (H301, H302, H317, H318, H360, H400, H410, H311) in the chemicals database but is restricted in EU cosmetics at max II/395.
Compliance Tools
Check OXYQUINOLINE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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