What is the GHS hazard classification for Thiabendazole?
Thiabendazole (CAS 148-79-8) is classified under EU CLP Annex VI as Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H400; H410. Source: EU CLP Annex VI (ECHA).
Warning
GHS09
NOAEL Data
Cosmetic Ingredient
Thiabendazole
Also known as: TB, APL-luster, 4-(2-Benzimidazolyl)thiazole, Biogard, Bioguard (+15 more)
CAS 148-79-8
Thiabendazole (CAS 148-79-8) is a chemical substance with GHS signal word Warning; key hazard signal: H400; H410. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, EPA TRI.
Cross-Vertical Regulatory Divergence
Thiabendazole is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
79
SOURCE
Chemical inventory jurisdictions
Regulatory lists
60
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Thiabendazole
CAS Number
148-79-8
Molecular Formula
C10H7N3S
InChI Key
WJCNZQLZVWNLKY-UHFFFAOYSA-N
Monoisotopic Mass
201.036068
Synonyms
TBAPL-luster4-(2-Benzimidazolyl)thiazoleBiogardBioguardBRN 0611403Captan TCaswell No. 849AEINECS 205-725-8EPA Pesticide Chemical Code 060101Helmindrax octelminMetasol TK-100
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Aquatic Acute 1; Aquatic Chronic 1 | H400; H410 | GHS09 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
BiocideDegradant/impurityProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| detected; general_foods; Pesticides; residue | FDA | United States Food and Drug Administration (FDA) |
| baby_food; detected; Pesticides; residue | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 79 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.1 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =0.1 | mg/kg bw | ARfD | - | Consumers | EFSA |
| 0 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 3 | unitless | EPA Classification | Inhalation | - | NTP ICE acute inhalation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 4 | unitless | EPA Classification | Inhalation | - | NTP ICE acute inhalation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| =2 | Unitless | EPA classification | oral | Rat (Female) | NTP ICE acute oral |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP ICE acute oral |
| 4 | unitless | EPA classification | Dermal | Rat | NTP ICE acute dermal |
| =4 | Unitless | EPA classification | oral | Rat | NTP ICE acute oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP ICE skin irritation |
| N1Q45E87DT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.1382 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 1 | unitless | GHS Classification | Dermal | Guinea pig | NTP ICE skin sensitization |
| 2 | unitless | GHS Classification | Inhalation | - | NTP ICE acute inhalation |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP ICE acute oral |
| 5 | unitless | GHS classification | Dermal | Rat | NTP ICE acute dermal |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP ICE acute oral |
| =5 | Unitless | GHS classification | oral | Rat | NTP ICE acute oral |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.552e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| range0.052 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 0.53 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2.54 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 2.55 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 2.57 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2.59 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =310 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| =2080 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3100 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3129 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| >5000 | mg/kg | LD50 | Dermal | Rat | NTP ICE acute dermal |
| =5000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| =6.95 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =6.95 | mg/kg bw/day | LEL | oral | mouse (cd1; Crl:CD) | EPA ToxRefDB v3 |
| =7.8 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =7.8 | mg/kg bw/day | LEL | oral | mouse (cd1; Crl:CD) | EPA ToxRefDB v3 |
| =10 | mg/kg bw/day | LEL | oral | Dog | ToxValDB ToxRefDB |
| =10 | mg/kg bw/day | LEL | oral | rat (sprague dawley; CD(SD)BR) | EPA ToxRefDB v3 |
| =25 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =25 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley (CD)) | EPA ToxRefDB v3 |
| =30.1 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =30.1 | mg/kg bw/day | LEL | oral | rat (sprague dawley; CD(SD)BR) | EPA ToxRefDB v3 |
| =37 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =37 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley (CD)) | EPA ToxRefDB v3 |
| =38 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =38 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley (CD)) | EPA ToxRefDB v3 |
| =40 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =40 | mg/kg bw/day | LEL | oral | rat (sprague dawley; CD(SD)BR) | EPA ToxRefDB v3 |
Showing 50 of 79 studies
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Thiabendazole | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
THIABENDAZOLE
ChEMBL Phase
4
Adverse Events
0
Bioactivity
19
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E233 — ADI: 0.1 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Thiabendazole?
Thiabendazole has 79 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
What regulatory lists include Thiabendazole?
Thiabendazole appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, detected; Europe; fruits_and_vegetables; Pesticides; residue, active_ingredient; Europe; Pesticides, and 5 more. Source: EPA CPDat.
Is Thiabendazole used in cosmetics?
Yes, Thiabendazole is also indexed as a cosmetic ingredient under the name Thiabendazole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Thiabendazole come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Thiabendazole have different safety status in cosmetics vs industrial chemicals?
Thiabendazole is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
Is Thiabendazole used outside industrial chemicals?
Thiabendazole also appears in cosmetics, pharmaceutical, food safety, cannabis databases.