What is the GHS hazard classification for Thiabendazole?
Thiabendazole (CAS 148-79-8) is classified under EU CLP Annex VI as Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H400; H410. Source: EU CLP Annex VI (ECHA).
Warning
GHS09
NOAEL Data
Cosmetic Ingredient
Thiabendazole
Also known as: TB, APL-luster, 4-(2-Benzimidazolyl)thiazole, Biogard, Bioguard (+15 more)
CAS 148-79-8
Thiabendazole (CAS 148-79-8) is a chemical substance with GHS signal word Warning; key hazard signal: H400; H410. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, EPA TRI.
Cross-Vertical Regulatory Divergence
Thiabendazole is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Thiabendazole
CAS Number
148-79-8
DTXSID
DTXSID0021337
Molecular Formula
C10H7N3S
InChI Key
WJCNZQLZVWNLKY-UHFFFAOYSA-N
Monoisotopic Mass
201.036068
Synonyms
TBAPL-luster4-(2-Benzimidazolyl)thiazoleBiogardBioguardBRN 0611403Captan TCaswell No. 849AEINECS 205-725-8EPA Pesticide Chemical Code 060101Helmindrax octelminMetasol TK-100
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Aquatic Acute 1; Aquatic Chronic 1 | H400; H410 | GHS09 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
BiocideDegradant/impurityProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | European Commission | CPCat |
| detected; Europe; fruits_and_vegetables; Pesticides; residue | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| detected; general_foods; Pesticides; residue | FDA | United States Food and Drug Administration (FDA) |
| baby_food; detected; Pesticides; residue | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.1 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.1 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 3 | unitless | EPA Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| =2 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 4 | unitless | EPA classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =4 | Unitless | EPA classification | oral | Rat | NTP_ICE_acute_oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| N1Q45E87DT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N1Q45E87DT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N1Q45E87DT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N1Q45E87DT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.1382 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 1 | unitless | GHS Classification | Dermal | Guinea pig | NTP_ICE_skin_sensitization |
| 2 | unitless | GHS Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 5 | unitless | GHS classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =5 | Unitless | GHS classification | oral | Rat | NTP_ICE_acute_oral |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 15520 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| range0.052 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.53 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2.54 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.55 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.57 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2.59 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =310 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =2080 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3100 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3129 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| >5000 | mg/kg | LD50 | Dermal | Rat | NTP_ICE_acute_dermal |
| =5000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =5000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =6.95 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =6.95 | mg/kg bw/day | LEL | oral | mouse (cd1; Crl:CD) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =7.8 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =7.8 | mg/kg bw/day | LEL | oral | mouse (cd1; Crl:CD) | ToxRefDB_ToxRefDB_v3_pod.csv |
Showing 50 of 100 studies
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Thiabendazole | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
THIABENDAZOLE
ChEMBL Phase
4
Adverse Events
0
Bioactivity
19
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E233 — ADI: 0.1 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Thiabendazole?
Thiabendazole has 100 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
What regulatory lists include Thiabendazole?
Thiabendazole appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, detected; Europe; fruits_and_vegetables; Pesticides; residue, active_ingredient; Europe; Pesticides, and 5 more. Source: EPA CPDat.
Is Thiabendazole used in cosmetics?
Yes, Thiabendazole is also indexed as a cosmetic ingredient under the name Thiabendazole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Thiabendazole come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Thiabendazole have different safety status in cosmetics vs industrial chemicals?
Thiabendazole is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
Is Thiabendazole used outside industrial chemicals?
Thiabendazole also appears in cosmetics, pharmaceutical, food safety, cannabis databases.