What is the NOAEL for Sodium hydroxymethanesulfinate?
Sodium hydroxymethanesulfinate has 12 NOAEL studies in the database. The lowest reported value is 4.94 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium hydroxymethanesulfinate
Also known as: Methanesulfinic acid, hydroxy-, monosodium salt, Discolite, EINECS 205-739-4, Formaldehyde sodium bisulfite adduct, Hydrosulfite AWC (+6 more)
CAS 149-44-0
Sodium hydroxymethanesulfinate (CAS 149-44-0) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Sodium Oxymethylene Sulfoxylate →
Cross-Vertical Regulatory Divergence
Sodium hydroxymethanesulfinate is classified GHS CMR hazard (H341, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Sodium hydroxymethanesulfinate
CAS Number
149-44-0
DTXSID
DTXSID7027120
Molecular Formula
CH4O3S.Na
InChI Key
XWGJFPHUCFXLBL-UHFFFAOYSA-M
Synonyms
Methanesulfinic acid, hydroxy-, monosodium saltDiscoliteEINECS 205-739-4Formaldehyde sodium bisulfite adductHydrosulfite AWCSodium oxymethanesulfinic acidNatrium hydroxymethansulfinatNatrium formaldehydesulfoxylatHydroxymethansulfinsaeure, natriumsalzOxymethansulfinsaeuren natriumUNII-X4ZGP7K714
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Reducing agentChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.94 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =21 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| X4ZGP7K714 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X4ZGP7K714 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X4ZGP7K714 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X4ZGP7K714 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =600 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium hydroxymethanesulphinate | 205-739-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM FORMALDEHYDE SULFOXYLATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Sodium hydroxymethanesulfinate?
Sodium hydroxymethanesulfinate appears on 2 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Sodium hydroxymethanesulfinate used in cosmetics?
Yes, Sodium hydroxymethanesulfinate is also indexed as a cosmetic ingredient under the name Sodium Oxymethylene Sulfoxylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium hydroxymethanesulfinate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Sodium hydroxymethanesulfinate have different safety status in cosmetics vs industrial chemicals?
Sodium hydroxymethanesulfinate is classified GHS CMR hazard (H341, H361) in the chemicals database but is allowed in EU cosmetics.
Is Sodium hydroxymethanesulfinate used outside industrial chemicals?
Sodium hydroxymethanesulfinate also appears in cosmetics, pharmaceutical databases.