Is Sodium Oxymethylene Sulfoxylate safe in cosmetics?
Sodium Oxymethylene Sulfoxylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Sodium Oxymethylene Sulfoxylate
Also known as: Methanesulfinic acid, hydroxy-, monosodium salt, Discolite, EINECS 205-739-4, Formaldehyde sodium bisulfite adduct, Hydrosulfite AWC (+6 more)
INCI: SODIUM OXYMETHYLENE SULFOXYLATE
Sodium Oxymethylene Sulfoxylate (CAS 149-44-0) is a cosmetic cosmetic ingredient functioning as Reducing agent – changes chemical nature by adding hydrogen or removing oxygen. NOAEL 100 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 149-44-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Oxymethylene Sulfoxylate is classified GHS CMR hazard (H341, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Reducing agent – changes chemical nature by adding hydrogen or removing oxygen
Safety Rating
MODERATE
Chemistry & Identifiers
InChIKey
SAJLIOLJORWJIO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; no specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Oxymethylene Sulfoxylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Sodium Oxymethylene Sulfoxylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =600 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Oxymethylene Sulfoxylate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A human skin and eye irritant. /Formaldehyde/ | A human skin and eye irritant. /Formaldehyde/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Reducing agent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Oxymethylene Sulfoxylate.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Oxymethylene Sulfoxylate by CAS number or substance name.
Studies
3
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Methanesulfinic acid, hydroxy-, monosodium salt
Discolite
EINECS 205-739-4
Formaldehyde sodium bisulfite adduct
Hydrosulfite AWC
Sodium oxymethanesulfinic acid
Natrium hydroxymethansulfinat
Natrium formaldehydesulfoxylat
Hydroxymethansulfinsaeure, natriumsalz
Oxymethansulfinsaeuren natrium
UNII-X4ZGP7K714
Chemical Function
Reducing agent
Chemical reaction regulator
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM FORMALDEHYDE SULFOXYLATE
ChEMBL ID
CHEMBL2107242
Max Phase
-1
Frequently Asked Questions
Is Sodium Oxymethylene Sulfoxylate allowed in the EU?
Sodium Oxymethylene Sulfoxylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Oxymethylene Sulfoxylate do in cosmetics?
Sodium Oxymethylene Sulfoxylate functions as: Reducing agent – changes chemical nature by adding hydrogen or removing oxygen. It is classified as a cosmetic ingredient in our database. CAS number: 149-44-0.
What is the NOAEL for Sodium Oxymethylene Sulfoxylate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Oxymethylene Sulfoxylate is =300 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Sodium Oxymethylene Sulfoxylate used outside cosmetics?
Sodium Oxymethylene Sulfoxylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Oxymethylene Sulfoxylate have different safety status in cosmetics vs industrial chemicals?
Sodium Oxymethylene Sulfoxylate is classified GHS CMR hazard (H341, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Sodium Oxymethylene Sulfoxylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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