NOAEL Data REACH Registered Cosmetic Ingredient

2,6-Dihydroxyethylaminotoluene

Also known as: UNII-I50F7J73SU, 2,6-Bis((2-hydroxyethyl)amino)toluene, Ethanol, 2,2'-((2-methyl-1,3-phenylene)diimino)bis-, Colorex VAS, H.C. Violett AS (+1 more)

CAS 149330-25-6

2,6-Dihydroxyethylaminotoluene (CAS 149330-25-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2,6-Dihydroxyethylaminotoluene →

Cross-Vertical Regulatory Divergence

2,6-Dihydroxyethylaminotoluene is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H317, H319, H412).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields

Name

2,6-Dihydroxyethylaminotoluene

CAS Number

149330-25-6

DTXSID

DTXSID30164225

Molecular Formula

C11H18N2O2

InChI Key

FGYCMSFOZIRDLN-UHFFFAOYSA-N

Monoisotopic Mass

210.136828

Synonyms

UNII-I50F7J73SU2,6-Bis((2-hydroxyethyl)amino)tolueneEthanol, 2,2'-((2-methyl-1,3-phenylene)diimino)bis-Colorex VASH.C. Violett ASHC Purple BS

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 63 studies

Value	Unit	Endpoint	Route	Species	Source
100	mg/kg	-	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
200	mg/kg bw	-	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
200	mg/kg bw	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
200	mg/kg bw	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
I50F7J73SU	UNII	FDA UNII substance identifier	-	-	openFDA substances
I50F7J73SU	UNII	FDA UNII substance identifier	-	-	openFDA substances
I50F7J73SU	UNII	FDA UNII substance identifier	-	-	openFDA substances
I50F7J73SU	UNII	FDA UNII substance identifier	-	-	openFDA substances
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=-	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=-	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=-	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=-	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.036	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.036	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.036	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.036	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=84	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=84	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=84	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=84	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw/d	NOAEL	-	-	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	dermal	-	SCCNFP_vision_codex
=100	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
=100	mg/kg bw/d	NOAEL	-	-	SCCS_vision_codex
=100	mg/kg bw/d	NOAEL	-	-	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	dermal	-	SCCNFP_vision_codex
=100	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
=100	mg/kg bw/day	NOAEL	dermal	-	SCCNFP_vision_codex
=100	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
=100	mg/kg bw/d	NOAEL	-	-	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	dermal	-	SCCNFP_vision_codex
=100	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=0.036	mg/kg bw/d	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 63 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-[3-(2-hydroxyethylamino)-2-methylanilino]ethanol	443-210-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1563/15	25 June 2015	safe	1.0%	secondary amine; nitrosamine <50ppb
SCCS/1448/11	20 September 2011	safe	1.0%	secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

1.0%

Frequently Asked Questions

What is the NOAEL for 2,6-Dihydroxyethylaminotoluene?

2,6-Dihydroxyethylaminotoluene has 63 NOAEL studies in the database. The lowest reported value is 100 mg/kg via oral in rat. Source: UnifiedCodex:SCCNFP:beta.noael_studies.

What regulatory lists include 2,6-Dihydroxyethylaminotoluene?

2,6-Dihydroxyethylaminotoluene appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 2,6-Dihydroxyethylaminotoluene used in cosmetics?

Yes, 2,6-Dihydroxyethylaminotoluene is also indexed as a cosmetic ingredient under the name 2,6-Dihydroxyethylaminotoluene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,6-Dihydroxyethylaminotoluene come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2,6-Dihydroxyethylaminotoluene have different safety status in cosmetics vs industrial chemicals?

2,6-Dihydroxyethylaminotoluene is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H317, H319, H412).

Is 2,6-Dihydroxyethylaminotoluene used outside industrial chemicals?

2,6-Dihydroxyethylaminotoluene also appears in cosmetics databases.