Good Cosmetic Ingredient NOAEL Data

2,6-Dihydroxyethylaminotoluene

INCI: 2,6-DIHYDROXYETHYLAMINOTOLUENE

CAS Number
149330-25-6
Function
Hair Dyeing (oxidative hair dye)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
EU Max Conc. 1.0%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under coal tar hair dye exemption

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 2,6-Dihydroxyethylaminotoluene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 100 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Prohibited in EU; permitted in US under coal tar hair dye exemption. Mixing ratio must be printed on label for oxidative hair dye products only.

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

eu_cosing_listed

Frequently Asked Questions

Is 2,6-Dihydroxyethylaminotoluene safe in cosmetics?

Prohibited in EU; permitted in US under coal tar hair dye exemption. Mixing ratio must be printed on label for oxidative hair dye products only. The EU classifies 2,6-Dihydroxyethylaminotoluene as "prohibited". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is 2,6-Dihydroxyethylaminotoluene allowed in the EU?

2,6-Dihydroxyethylaminotoluene EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,6-Dihydroxyethylaminotoluene do in cosmetics?

2,6-Dihydroxyethylaminotoluene functions as: Hair Dyeing (oxidative hair dye). It is classified as a cosmetic ingredient in our database. CAS number: 149330-25-6.

What is the Margin of Safety for 2,6-Dihydroxyethylaminotoluene?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2,6-Dihydroxyethylaminotoluene?

The NOAEL (No Observed Adverse Effect Level) for 2,6-Dihydroxyethylaminotoluene is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

๐Ÿ“ฑ

Is 2,6-Dihydroxyethylaminotoluene in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2,6-Dihydroxyethylaminotoluene in your formulation.