Is 2,6-Dihydroxyethylaminotoluene safe in cosmetics?
2,6-Dihydroxyethylaminotoluene has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2,6-Dihydroxyethylaminotoluene
Also known as: UNII-I50F7J73SU, 2,6-Bis((2-hydroxyethyl)amino)toluene, Ethanol, 2,2'-((2-methyl-1,3-phenylene)diimino)bis-, Colorex VAS, H.C. Violett AS (+1 more)
INCI: 2,6-DIHYDROXYETHYLAMINOTOLUENE
2,6-Dihydroxyethylaminotoluene (CAS 149330-25-6) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (oxidative hair dye). Reported NOAEL =100 mg/kg bw/day (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited, max 1.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 149330-25-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,6-Dihydroxyethylaminotoluene is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H317, H319, H412).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing (oxidative hair dye)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[3-(2-hydroxyethylamino)-2-methylanilino]ethanol
InChIKey
FGYCMSFOZIRDLN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
1.0%
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,6-Dihydroxyethylaminotoluene.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2,6-Dihydroxyethylaminotoluene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rat | sensitisation | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rat | sensitisation | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rat | sensitisation | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
17.7%
KeratinoSens IC50
2000 µM
hCLAT CV75
1000 µg/mL
LLNA EC3
50%
NESIL
12500 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
BRIN Brazil/India Cosmetics
India: Restricted
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_hair_dye | - | Oxidative hair dye |
| KR | prohibited | - | - |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "149330-25-6", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "other", "molecular_weight_Da": "211.26", "color_result_on_hair": "Violet modifier", "shade_range": "brown", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex", "sensit…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2,6-Dihydroxyethylaminotoluene.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2,6-Dihydroxyethylaminotoluene by CAS number or substance name.
Studies
40
Lowest NOAEL
0
Highest NOAEL
200
Units vary across source rows: mg/kg bw/d, mg/kg bw, mg/kg bw/day
SCCS_vision_codex
SCCNFP_vision_codex
Known Synonyms
UNII-I50F7J73SU
2,6-Bis((2-hydroxyethyl)amino)toluene
Ethanol, 2,2'-((2-methyl-1,3-phenylene)diimino)bis-
Colorex VAS
H.C. Violett AS
HC Purple BS
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is 2,6-Dihydroxyethylaminotoluene allowed in the EU?
2,6-Dihydroxyethylaminotoluene EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Dihydroxyethylaminotoluene do in cosmetics?
2,6-Dihydroxyethylaminotoluene functions as: Hair Dyeing (oxidative hair dye). It is classified as a cosmetic ingredient in our database. CAS number: 149330-25-6.
What is the NOAEL for 2,6-Dihydroxyethylaminotoluene?
The NOAEL (No Observed Adverse Effect Level) for 2,6-Dihydroxyethylaminotoluene is =100 mg/kg bw/day based on a repeated dose toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is 2,6-Dihydroxyethylaminotoluene used outside cosmetics?
2,6-Dihydroxyethylaminotoluene also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,6-Dihydroxyethylaminotoluene have different safety status in cosmetics vs industrial chemicals?
2,6-Dihydroxyethylaminotoluene is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H317, H319, H412).
Compliance Tools
Check 2,6-Dihydroxyethylaminotoluene compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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