Also known as: Aziridine, 5-20-01-00003, 1H-Azirine, dihydro-, BRN 0102380, Dihydroazirene (+8 more)
CAS 151-56-4
Ethyleneimine (CAS 151-56-4) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H350; H340; H330; H310; H300; H314; H411. Key regulatory status: California Proposition 65, REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Ethyleneimine is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H350, H340, H330, H310, H300, H314, H411).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1998 | 9, Sup 7, 71 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Carc. 1B; Muta. 1B; Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; Skin Corr. 1B; Aquatic Chronic 2 | H225; H350; H340; H330; H310; H300; H314; H411 | GHS02; GHS08; GHS06; GHS05; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. The substance may cause effects on the central nervous system, kidneys and liver. Exposure far above the OEL could cause death. The effects may be delayed. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans. May cause heritable genetic damage to human germ cells. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | Ca | - | - | N |
| ACGIH | TWA | 0.05 ppm [2008] | 0.05 | - | Y |
| ACGIH | STEL | 0.1 ppm [2008] | 0.1 | - | Y |
| CAL/OSHA | TWA | 0.5 ppm (1 mg/m³) | 0.5 | 1 | Y |
| NIOSH | IDLH | 100 ppm | 100 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; Food contact items; Toys and children's products | Danish EPA | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQE0.01 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE0.01 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE0.01 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE0.01 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 54P5FEX9FH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 54P5FEX9FH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 54P5FEX9FH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 54P5FEX9FH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.0616 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.1 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.1021 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.3257 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.4559 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.4718 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.9594 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.4769 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 4.5031 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =15 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =58130.2 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =8.80761 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~1.03 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 29 of 29 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Aziridine | 205-793-9 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Ethyleneimine (Aziridine) | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Ethyleneimine (CAS 151-56-4) is classified under EU CLP Annex VI as Flam. Liq. 2; Carc. 1B; Muta. 1B; Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; Skin Corr. 1B; Aquatic Chronic 2 with signal word Danger. Hazard statements: H225; H350; H340; H330; H310; H300; H314; H411. Source: EU CLP Annex VI (ECHA).
Ethyleneimine has 29 NOAEL studies in the database. The lowest reported value is 0.01 ug/day. Source: California Proposition 65.
Ethyleneimine appears on 6 regulatory/inventory lists including banned; Europe; Personal care, drinking_water; Europe; manufacturing; plastic_additive, OEHHA Proposition 65 (3/2019), and 3 more. Source: EPA CPDat.
Ethyleneimine is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Ethyleneimine is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for Ethyleneimine are set by OSHA, ACGIH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Ethyleneimine is also indexed as a cosmetic ingredient under the name Aziridine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Ethyleneimine is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H350, H340, H330, H310, H300, H314, H411).
Ethyleneimine also appears in cosmetics, pharmaceutical databases.