Moderate Cosmetic Ingredient GHS Classified

Aziridine

INCI: AZIRIDINE (SYNONYM: ETHYLENIMINE)

CAS Number
151-56-4
Function
None in cosmetics - industrial chemical monomer/intermediate
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Prohibited - classified as a known carcinogen (IARC Group 2B; NTP reasonably anticipated); not permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. The substance may cause effects on the central nervous system, kidneys and liver. Exposure far above the OEL could cause death. The effects may be delayed.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans. May cause heritable genetic damage to human germ cells.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Expert Verdict

Extremely hazardous - fatal if swallowed (H300), fatal in contact with skin (H310), fatal if inhaled (H330), may cause cancer (H350, Category 1B), may cause genetic defects (H340, Category 1B), causes severe skin burns and eye damage (H314), toxic to aquatic life (H411). A three-membered nitrogen heterocycle that is highly reactive; used industrially in polymer chemistry but absolutely prohibited in any consumer-facing cosmetic product due to extreme toxicity, carcinogenicity, and mutagenicity

⚠️
Concern Level: High

Regulatory Flags

prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Aziridine safe in cosmetics?

Extremely hazardous - fatal if swallowed (H300), fatal in contact with skin (H310), fatal if inhaled (H330), may cause cancer (H350, Category 1B), may cause genetic defects (H340, Category 1B), causes severe skin burns and eye damage (H314), toxic to aquatic life (H411). A three-membered nitrogen heterocycle that is highly reactive; used industrially in polymer chemistry but absolutely prohibited in any consumer-facing cosmetic product due to extreme toxicity, carcinogenicity, and mutagenicity The EU classifies Aziridine as "prohibited". Safety rating: MODERATE.

Is Aziridine allowed in the EU?

Aziridine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Aziridine do in cosmetics?

Aziridine functions as: None in cosmetics - industrial chemical monomer/intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 151-56-4.

What is the Margin of Safety for Aziridine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Aziridine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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