What is the NOAEL for 4,4'-Bis(2-benzoxazolyl)stilbene?
4,4'-Bis(2-benzoxazolyl)stilbene has 5 NOAEL studies in the database. The lowest reported value is 44.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4,4'-Bis(2-benzoxazolyl)stilbene
Also known as: Benzoxazole, 2,2'-(1,2-ethenediyldi-4,1-phenylene)bis-, Benzoxazole, 2,2'-(vinylenedi-p-phenylene)bis-, 2,2'-(1,2-Ethenediyldi-4,1-phenylene)bis[benzoxazole], 2,2'-(Vinylenedi-4-phenylene)bis(benzoxazole), 2,2'-(Vinylenedi-p-phenylene)bisbenzoxazole (+13 more)
CAS 1533-45-5
4,4'-Bis(2-benzoxazolyl)stilbene (CAS 1533-45-5) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Fluorescent Brightener 393 →
Cross-Vertical Regulatory Divergence
4,4'-Bis(2-benzoxazolyl)stilbene is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
4,4'-Bis(2-benzoxazolyl)stilbene
CAS Number
1533-45-5
DTXSID
DTXSID4051744
Molecular Formula
C28H18N2O2
InChI Key
ORACIQIJMCYPHQ-UHFFFAOYSA-N
Monoisotopic Mass
414.136828
Synonyms
Benzoxazole, 2,2'-(1,2-ethenediyldi-4,1-phenylene)bis-Benzoxazole, 2,2'-(vinylenedi-p-phenylene)bis-2,2'-(1,2-Ethenediyldi-4,1-phenylene)bis[benzoxazole]2,2'-(Vinylenedi-4-phenylene)bis(benzoxazole)2,2'-(Vinylenedi-p-phenylene)bisbenzoxazole4,4'-Di(benzoxazol-2-yl)stilbeneBenetex OB 1C.I. 40674C.I. Fluorescent Brightener 393Eastobrite OB 1Eastobrite OB 3Fluorescent Brightener 393
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
DyeBrightener
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =44.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 128BY3ERD5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 128BY3ERD5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 128BY3ERD5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 128BY3ERD5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2'-(vinylenedi-p-phenylene)bisbenzoxazole | 216-245-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include 4,4'-Bis(2-benzoxazolyl)stilbene?
4,4'-Bis(2-benzoxazolyl)stilbene appears on 2 regulatory/inventory lists including Indirect additives food contact (10/2018), inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is 4,4'-Bis(2-benzoxazolyl)stilbene used in cosmetics?
Yes, 4,4'-Bis(2-benzoxazolyl)stilbene is also indexed as a cosmetic ingredient under the name Fluorescent Brightener 393. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4,4'-Bis(2-benzoxazolyl)stilbene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 4,4'-Bis(2-benzoxazolyl)stilbene have different safety status in cosmetics vs industrial chemicals?
4,4'-Bis(2-benzoxazolyl)stilbene is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H411).
Is 4,4'-Bis(2-benzoxazolyl)stilbene used outside industrial chemicals?
4,4'-Bis(2-benzoxazolyl)stilbene also appears in cosmetics databases.