Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Fluorescent Brightener 393. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 190 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 800 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 190 mg/kg bw/day | oral | code:3544 | oral | REACH |
Expert Verdict
Primarily an industrial-grade stilbene derivative with limited cosmetic-specific toxicological data; degrades under extreme pH and prolonged UV exposure; no dedicated SCCS opinion for cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is Fluorescent Brightener 393 safe in cosmetics?
Primarily an industrial-grade stilbene derivative with limited cosmetic-specific toxicological data; degrades under extreme pH and prolonged UV exposure; no dedicated SCCS opinion for cosmetic use. The EU classifies Fluorescent Brightener 393 as "prohibited". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Fluorescent Brightener 393 allowed in the EU?
Fluorescent Brightener 393 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Fluorescent Brightener 393 do in cosmetics?
Fluorescent Brightener 393 functions as: Colorant (fluorescent whitening agent — absorbs UV and re-emits as blue visible light). It is classified as a cosmetic ingredient in our database. CAS number: 1533-45-5.
What is the Margin of Safety for Fluorescent Brightener 393?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Fluorescent Brightener 393?
The NOAEL (No Observed Adverse Effect Level) for Fluorescent Brightener 393 is 190 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
Check Fluorescent Brightener 393 compliance across multiple jurisdictions:
Related Ingredients
Is Fluorescent Brightener 393 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Fluorescent Brightener 393 in your formulation.