Danger GHS05GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate

Also known as: UNII-04N8KX12N6, 1-(2-Hydroxyethyl)-4,5-diaminopyrazole sulfate, 1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate (1:1), 1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate, 1-Hydroxyethyl 4,5-diamino pyrazole sulfate (+2 more)

CAS 155601-30-2

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate (CAS 155601-30-2) is a chemical substance with GHS signal word Danger; key hazard signal: H318; H317; H411. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate →

SOURCE NOAEL studies
NOAEL studies
33
SOURCE Chemical inventory jurisdictions
Regulatory lists
5
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate
CAS Number
155601-30-2
Molecular Formula
C5H10N4O.H2O4S
InChI Key
IBCDZZHMNXXYAP-UHFFFAOYSA-N
Monoisotopic Mass
240.052841
Synonyms
UNII-04N8KX12N61-(2-Hydroxyethyl)-4,5-diaminopyrazole sulfate1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate (1:1)1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate1-Hydroxyethyl 4,5-diamino pyrazole sulfate4,5-Diamino-1-(2-hydroxyethyl)-1H-pyrazole sulfateColorex WP5

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 2H318; H317; H411GHS05; GHS07; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 33 of 33 studies
ValueUnitEndpointRouteSpeciesSource
250--oral gavageSprague Dawley ratsRegulatory source
250mg/kg bw/day---Regulatory source
300--oral gavageSprague-Dawley ratsRegulatory source
300--oral gavage (maternal dosing)Sprague-Dawley ratsRegulatory source
900--oral gavage (maternal dosing)Sprague-Dawley ratsRegulatory source
900mg/kg/day--ratRegulatory source
1000--oral gavageSprague-Dawley ratsRegulatory source
04N8KX12N6UNIIFDA UNII substance identifier--openFDA substances
>2000mg/kg bwLD50oralRatNTP ICE acute oral
800mg/kg bw/dayLOAELoralratCOSMOS DB
=0.02mg/kg bw/dNOAELoralratSCCS Opinion
250mg/kg bw/dayNOAELoralratCOSMOS DB
=250mg/ kg body weight/dNOAELoralratCIR Safety Assessment
=250-NOAELoral gavageSprague Dawley ratsCIR Safety Assessment
=250mg/kg bw/dayNOAEL--SCCS Opinion
=250mg/kg bw/dNOAELoralratSCCS Opinion
=300mg/kg body weight/dNOAELoralratCIR Safety Assessment
=300-NOAELoral gavageSprague-Dawley ratsCIR Safety Assessment
=300mg/kg bwNOAEL--SCCS Opinion
=300mg/kgNOAELoralratSCCS Opinion
=300mg/kg bwNOAELoralratSCCS Opinion
=300mg/kg bw/ dayNOAELoralratSCCS Opinion
=900mg/kg body weight/dNOAELoralratCIR Safety Assessment
=900-NOAELoral gavage (maternal dosing)Sprague-Dawley ratsCIR Safety Assessment
=900mg/kg bwNOAEL--SCCS Opinion
=900mg/kg/dayNOAEL-ratSCCS Opinion
=900mg/kg bwNOAEL-ratSCCS Opinion
=1000mg/kg body weight/dayNOAEL-ratCIR Safety Assessment
=1000-NOAELoral gavageSprague-Dawley ratsCIR Safety Assessment
=1000mg/kg bw/dayNOAEL--SCCS Opinion
=1000mg/kg bw/dayNOAEL-ratSCCS Opinion
=0.02mg/kg bw/ddermal absorptionoralratRegulatory source
=250mg/kg bw/ddermal absorptionoralratRegulatory source

Showing 33 of 33 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered1-(2-hydroxyethyl)-1H-pyrazol-4,5-diyldiammoniumsulfate429-300-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0990/062006-06-20The SCCP is of the opinion that the information submitted is inadequate to assess the safe use of the substance.-Information inadequate to assess safe use; required: in vitro percutaneous absorption study under oxidative conditions per Notes of Guidance, an appropriate mammalian cell gene mutation test in vitro, and genotoxicity/mutagenicity studies in finished hair dye formulations.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate (CAS 155601-30-2) is classified under EU CLP Annex VI as Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H318; H317; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate has 33 NOAEL studies in the database. The lowest reported value is 0.02 mg/kg bw/d via oral in rat. Source: SCCS Opinion.

What regulatory lists include 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate used in cosmetics?

Yes, 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate is also indexed as a cosmetic ingredient under the name 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate have different safety status in cosmetics vs industrial chemicals?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate is classified GHS Danger (H318, H317, H411) in the chemicals database but is restricted in EU cosmetics.

Is 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate used outside industrial chemicals?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate also appears in cosmetics databases.