1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate
INCI: 1-HYDROXYETHYL 4,5-DIAMINO PYRAZOLE SULFATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 800 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
SCCS flagged stability data in marketed products not reported; must comply with Annex III conditions; patch test recommended; diamino compound
Regulatory Flags
Frequently Asked Questions
Is 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate safe in cosmetics?
SCCS flagged stability data in marketed products not reported; must comply with Annex III conditions; patch test recommended; diamino compound The EU classifies 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate allowed in the EU?
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate do in cosmetics?
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate functions as: Hair dyeing oxidative hair colouring agent (precursor); COLIPA No. A154. It is classified as a cosmetic ingredient in our database. CAS number: 155601-30-2.
What is the Margin of Safety for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate?
The NOAEL (No Observed Adverse Effect Level) for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate is 250 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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