Also known as: UNII-04N8KX12N6, 1-(2-Hydroxyethyl)-4,5-diaminopyrazole sulfate, 1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate (1:1), 1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate, 4,5-Diamino-1-(2-hydroxyethyl)-1H-pyrazole sulfate (+1 more)
INCI: 1-HYDROXYETHYL 4,5-DIAMINO PYRAZOLE SULFATE
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate (CAS 155601-30-2) is a cosmetic cosmetic ingredient functioning as Hair dyeing oxidative hair colouring agent (precursor); COLIPA No. A154. Reported NOAEL =300 mg/kg body weight/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: restricted; 5 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 155601-30-2 →
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate is classified GHS Danger (H317, H318, H411) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =300 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =300 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =300 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =900 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =900 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =900 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =900 mg/kg body weight/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =1000 mg/kg body weight/day | - | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =1000 mg/kg body weight/day | - | rat | developmental toxicity | CIR_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: ATP01
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 3.0% | - | - | SCCP/0064 |
| measured | 4.0% | - | - | SCCP/0064 |
| measured | 0.8% | - | - | SCCP/0064 |
| measured | 1.7% | - | - | SCCP/0064 |
| measured | 2.2% | - | - | SCCP/0064 |
Expert safety assessment and concern-level summary for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate.
Public NOAEL study rows linked to 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate by CAS number or substance name.
Units vary across source rows: mg/kg body weight/d, mg/kg body weight/day, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 3.0% | - | - |
| 4.0% | - | - |
| 0.8% | - | - |
| 1.7% | - | - |
| 2.2% | - | - |
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate functions as: Hair dyeing oxidative hair colouring agent (precursor); COLIPA No. A154. It is classified as a cosmetic ingredient in our database. CAS number: 155601-30-2.
The NOAEL (No Observed Adverse Effect Level) for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate is =300 mg/kg body weight/d based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate is classified GHS Danger (H317, H318, H411) in the chemicals database but is restricted in EU cosmetics.
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