What is the NOAEL for Bisphenol A glycidyl methacrylate?
Bisphenol A glycidyl methacrylate has 13 NOAEL studies in the database. The lowest reported value is 3.113 ratio via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
Bisphenol A glycidyl methacrylate
Also known as: Bisphenol A-glycidyl methacrylate (2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis[4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)] ester), Bisphenol A-diglycidyl-dimethyl acrylate, Bisphenol(a)glycidylmethacrylate, BRN 2316426, EINECS 216-367-7 (+11 more)
CAS 1565-94-2
Bisphenol A glycidyl methacrylate (CAS 1565-94-2) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA) →
Cross-Vertical Regulatory Divergence
Bisphenol A glycidyl methacrylate is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Bisphenol A glycidyl methacrylate
CAS Number
1565-94-2
DTXSID
DTXSID7044841
Molecular Formula
C29H36O8
InChI Key
AMFGWXWBFGVCKG-UHFFFAOYSA-N
Monoisotopic Mass
512.241018
Synonyms
Bisphenol A-glycidyl methacrylate (2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis[4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)] ester)Bisphenol A-diglycidyl-dimethyl acrylateBisphenol(a)glycidylmethacrylateBRN 2316426EINECS 216-367-7Bis(Phenol A-Glycidyl Methacrylate), HomopolymerBis-GMA PolymerPoly(Bis-GMA)RetroplastNuvaSealPanavia OpaqueEnamel Bond, Concise
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Film formerMonomers
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 125.5 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 35.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 10.9 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 45.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 45.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 45.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 45.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 454I75YXY0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 454I75YXY0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 454I75YXY0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 454I75YXY0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 22.8 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 3.113 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1600257
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
Is Bisphenol A glycidyl methacrylate used in cosmetics?
Yes, Bisphenol A glycidyl methacrylate is also indexed as a cosmetic ingredient under the name Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Bisphenol A glycidyl methacrylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Bisphenol A glycidyl methacrylate have different safety status in cosmetics vs industrial chemicals?
Bisphenol A glycidyl methacrylate is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is restricted in EU cosmetics.
Is Bisphenol A glycidyl methacrylate used outside industrial chemicals?
Bisphenol A glycidyl methacrylate also appears in cosmetics, pharmaceutical databases.