Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA)

INCI: ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE

CAS Number
1565-94-2
Function
Film forming; widely used in nail enhancement products and dental composites
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR concluded safe for use in nail products where skin contact is avoided (2005, reaffirmed 2023)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Best-studied ingredient in this group; sensitization elicitation reported at <10 ppm in sensitized individuals; cross-reactivity with other methacrylates; BPA trace levels must be controlled; not suitable for skin-contact products; AICIS recommends poisons scheduling

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA) safe in cosmetics?

Best-studied ingredient in this group; sensitization elicitation reported at <10 ppm in sensitized individuals; cross-reactivity with other methacrylates; BPA trace levels must be controlled; not suitable for skin-contact products; AICIS recommends poisons scheduling The EU classifies Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA) as "restricted". Safety rating: MODERATE.

Is Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA) allowed in the EU?

Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA) do in cosmetics?

Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA) functions as: Film forming; widely used in nail enhancement products and dental composites. It is classified as a cosmetic ingredient in our database. CAS number: 1565-94-2.

What is the Margin of Safety for Isopropylidenediphenyl Bisoxyhydroxypropyl Methacrylate (bis-GMA)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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