What is the NOAEL for 2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate?
2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate has 20 NOAEL studies in the database. The lowest reported value is 0.83 mg/kg bw/d via oral in rat. Source: SCCS Opinion.
NOAEL Data
Cosmetic Ingredient
2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate
CAS 1603-02-7
2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate (CAS 1603-02-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
View cosmetic safety profile for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE →
SOURCE
NOAEL studies
NOAEL studies
20
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
5 fields
Name
2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate
CAS Number
1603-02-7
Molecular Formula
C4H7N5O4S
InChI Key
DJUGBKWOBAOTFA-UHFFFAOYSA-N
Monoisotopic Mass
221.021875
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 200 | mg/kg bw/day | - | - | - | Regulatory source |
| 1000 | mg/kg bw/day | - | - | human | Regulatory source |
| 1000 | mg/kg bw/day | - | - | - | Regulatory source |
| T3YK834X4U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.83 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =100 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =200 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =200 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =200 | mg/kg bw | NOAEL | oral | rat | SCCNFP Opinion |
| =1000 | mg/kg bw/day | NOAEL | - | human | SCCS Opinion |
| =1000 | mg/kg bw | NOAEL | - | rat | SCCNFP Opinion |
| =0.83 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =100 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =200 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 1000 | mg/kg bw | dermal absorption | - | rat | Regulatory source |
| 200 | mg/kg bw/day | genotoxicity | - | - | Regulatory source |
| 200 | mg/kg bw | repeated dose toxicity | oral | rat | Regulatory source |
| 200 | mg/kg bw | repeated dose toxicity | dermal | rabbit | Regulatory source |
| 200 | mg/kg bw/day | repeated dose toxicity | oral | rat | Regulatory source |
Showing 20 of 20 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1561/15 | 25 June 2015 | safe | 0.5% | sensitisation potential not excluded |
| SCCP/1168/08 | 30 September 2008 | safe | 0.5% | sensitisation potential not excluded |
| SCCP/1122/07 | 30 September 2008 | The SCCP is of the opinion that the safe use of 2,5,6-triamino-4-pyrimidinol sulfate as an ingredient in oxidative hair dye formulations at a maximum concentration of 0.5% on the head cannot be assessed. | 0.5% | Safe use cannot be assessed at 0.5% on the head. The potential for induction of gene mutations has to be clarified. Genotoxicity/mutagenicity studies in finished hair dye formulations should be undertaken. A skin sensitising potential cannot be excluded. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
III/301
Category
Hair Dyes
Frequently Asked Questions
What regulatory lists include 2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate?
2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.
Is 2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate used in cosmetics?
Yes, 2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate is also indexed as a cosmetic ingredient under the name 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate used outside industrial chemicals?
2,5,6-Triaminopyrimidin-4-yl hydrogen sulfate also appears in cosmetics databases.