Moderate Cosmetic Ingredient NOAEL Data

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE

CAS Number
1603-02-7
Function
Hair Dyeing
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Restricted
EU Max Conc. III/301
๐Ÿ‡บ๐Ÿ‡ธ US Status Not specifically regulated

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Toxicological Studies

2 study endpoints found for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 50 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 50 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE is listed in the EU CosIng database with functions: Hair Dyeing It is restricted under EU Cosmetics Regulation. Restriction: III/301.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment eu_cosing_listed

Frequently Asked Questions

Is 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE safe in cosmetics?

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE is listed in the EU CosIng database with functions: Hair Dyeing It is restricted under EU Cosmetics Regulation. Restriction: III/301. The EU classifies 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE as "Restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE allowed in the EU?

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE EU regulatory status: Restricted. Maximum allowed concentration: III/301. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE do in cosmetics?

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 1603-02-7.

What is the NOAEL for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE?

The NOAEL (No Observed Adverse Effect Level) for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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