NOAEL Data REACH Registered Cosmetic Ingredient

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran

Also known as: 5-17-01-00256, BRN 0111348, EINECS 240-457-5, FEMA No. 3236, Pyran, 2-(2-methyl-1-propenyl)-4-methyltetrahydro- (+11 more)

CAS 16409-43-1

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran (CAS 16409-43-1) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Laevo-Rose Oxide →

SOURCE NOAEL studies
NOAEL studies
21
SOURCE Chemical inventory jurisdictions
Regulatory lists
7
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields
Name
4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran
CAS Number
16409-43-1
Molecular Formula
C10H18O
InChI Key
CZCBTSFUTPZVKJ-UHFFFAOYSA-N
Monoisotopic Mass
154.135765
Synonyms
5-17-01-00256BRN 0111348EINECS 240-457-5FEMA No. 3236Pyran, 2-(2-methyl-1-propenyl)-4-methyltetrahydro-2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropenyl)-Pyran, tetrahydro-4-methyl-2-(2-methylpropenyl)-RosenoxideRosoxideTetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyranTetrahydro-4-methyl-2-(2-methylpropenyl)-2H-pyranUNII-4O51437J50

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 56 records
FragranceDeodorizerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records
ListKeywordSource
EuropeEuropean CommissionFl@vis
air; Cleaning products and household care - laundry and fabric treatment; detected; emissionsElsevierCPCat
air; Cleaning products and household care; detected; emissionsElsevierCPCat
air; Cleaning products and household care - air freshener; detected; emissionsElsevierCPCat
IFRA TransparencyIFRAIFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
consumer_productP&GProctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 21 of 21 studies
ValueUnitEndpointRouteSpeciesSource
2.55%Concentration, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
1%Concentration, one positive responseDermalHumanNTP ICE skin sensitization
=1.2mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
4O51437J50UNIIFDA UNII substance identifier--openFDA substances
0%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
9.804%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
775ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
1350ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
4650ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
2372ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
930ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP ICE skin sensitization
=4300mg/kg bwLD50oralRatNTP ICE acute oral
>2.51mg/kg bw/dayNOAELoralRatECHA
2.805mg/kg bw/dayNOAELoralratCOSMOS DB
>2.81mg/kg bw/dayNOAELoralRatECHA
=50mg/kg bw/dayNOAELoralRatECHA
=100mg/kg bw/dayNOAELoralRatECHA
=300mg/kg bw/dayNOAELoralRatECHA
=1000mg/kg bw/dayNOAELoralRatECHA
=1152mg/kg bw/dayNOAELoralRatECHA
3unitlessRelative reliability scoreDermalHumanNTP ICE skin sensitization

Showing 21 of 21 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredTetrahydro-4-methyl-2-(2-methylprop-1-enyl)pyran240-457-5ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran has 21 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran appears on 7 regulatory/inventory lists including Europe, air; Cleaning products and household care - laundry and fabric treatment; detected; emissions, air; Cleaning products and household care; detected; emissions, and 4 more. Source: EPA CPDat.

Is 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran used in cosmetics?

Yes, 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran is also indexed as a cosmetic ingredient under the name Laevo-Rose Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran have different safety status in cosmetics vs industrial chemicals?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran is classified GHS CMR hazard (H315, H319, H361) in the chemicals database but is allowed in EU cosmetics.

Is 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran used outside industrial chemicals?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran also appears in cosmetics, cannabis databases.