Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Laevo-Rose Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2.805 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 2.805 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Fragrance ingredient with extremely potent odour threshold at 0.5 ppb requiring strict dosing control and compliance with IFRA 51st Amendment limits; patch-test sensitization possible at high concentrations.
Regulatory Flags
Frequently Asked Questions
Is Laevo-Rose Oxide safe in cosmetics?
Fragrance ingredient with extremely potent odour threshold at 0.5 ppb requiring strict dosing control and compliance with IFRA 51st Amendment limits; patch-test sensitization possible at high concentrations. The EU classifies Laevo-Rose Oxide as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Laevo-Rose Oxide allowed in the EU?
Laevo-Rose Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Laevo-Rose Oxide do in cosmetics?
Laevo-Rose Oxide functions as: Fragrance (declared as PARFUM on label). It is classified as a cosmetic ingredient in our database. CAS number: 16409-43-1.
What is the Margin of Safety for Laevo-Rose Oxide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Laevo-Rose Oxide?
The NOAEL (No Observed Adverse Effect Level) for Laevo-Rose Oxide is 2.805 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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