What is the NOAEL for 2-Amino-3-hydroxypyridine?
2-Amino-3-hydroxypyridine has 32 NOAEL studies in the database. The lowest reported value is 45 mg/kg bw/day. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Amino-3-hydroxypyridine
Also known as: EINECS 240-886-8, UNII-P8740PEW4B
CAS 16867-03-1
2-Amino-3-hydroxypyridine (CAS 16867-03-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 2-Amino-3-Hydroxypyridine →
Cross-Vertical Regulatory Divergence
2-Amino-3-hydroxypyridine is classified GHS Danger (H301, H302, H311, H315, H319, H335, H373, H411) in the chemicals database but is restricted in EU cosmetics at max 1.0%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
32
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
8 fields
Name
2-Amino-3-hydroxypyridine
CAS Number
16867-03-1
DTXSID
DTXSID50168588
Molecular Formula
C5H6N2O
InChI Key
BMTSZVZQNMNPCT-UHFFFAOYSA-N
Monoisotopic Mass
110.048013
Synonyms
EINECS 240-886-8UNII-P8740PEW4B
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 32 of 32 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 45 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| P8740PEW4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8740PEW4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8740PEW4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8740PEW4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 60 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =0.02 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.02 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.02 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.02 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| 30 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =30 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =30 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =30 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =30 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =30 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =0.02 | mg/kg bw | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =30 | mg/kg bw | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =30 | mg/kg bw | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | mg/kg bw/day | genotoxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | mg/kg bw/day | irritation | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg bw/day | irritation | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 32 of 32 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-aminopyridin-3-ol | 240-886-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1141/07 | 15 April 2008 | safe | 1.0% | sensitisation potential not excluded |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1.0%
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL4777856
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2-Amino-3-hydroxypyridine?
2-Amino-3-hydroxypyridine appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.
Is 2-Amino-3-hydroxypyridine used in cosmetics?
Yes, 2-Amino-3-hydroxypyridine is also indexed as a cosmetic ingredient under the name 2-Amino-3-Hydroxypyridine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Amino-3-hydroxypyridine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Amino-3-hydroxypyridine have different safety status in cosmetics vs industrial chemicals?
2-Amino-3-hydroxypyridine is classified GHS Danger (H301, H302, H311, H315, H319, H335, H373, H411) in the chemicals database but is restricted in EU cosmetics at max 1.0%.
Is 2-Amino-3-hydroxypyridine used outside industrial chemicals?
2-Amino-3-hydroxypyridine also appears in cosmetics, pharmaceutical databases.