2-Amino-3-Hydroxypyridine
INCI: 2-AMINO-3-HYDROXYPYRIDINE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for 2-Amino-3-Hydroxypyridine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 30 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 60 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for 2-Amino-3-Hydroxypyridine based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Expert Verdict
Oxidative use only — must be mixed with hydrogen peroxide before application; concentration limit is strict (1.0% on-head max); label must state mixing ratio and contain declaration of 2-Amino-3-Hydroxypyridine per Annex III conditions
Regulatory Flags
Frequently Asked Questions
Is 2-Amino-3-Hydroxypyridine safe in cosmetics?
Oxidative use only — must be mixed with hydrogen peroxide before application; concentration limit is strict (1.0% on-head max); label must state mixing ratio and contain declaration of 2-Amino-3-Hydroxypyridine per Annex III conditions The EU classifies 2-Amino-3-Hydroxypyridine as "restricted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is 2-Amino-3-Hydroxypyridine allowed in the EU?
2-Amino-3-Hydroxypyridine EU regulatory status: restricted. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Amino-3-Hydroxypyridine do in cosmetics?
2-Amino-3-Hydroxypyridine functions as: Hair Dyeing (oxidative hair dye). It is classified as a cosmetic ingredient in our database. CAS number: 16867-03-1.
What is the Margin of Safety for 2-Amino-3-Hydroxypyridine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Amino-3-Hydroxypyridine?
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-3-Hydroxypyridine is 30 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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