2-Amino-3-Hydroxypyridine (CAS 16867-03-1) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (oxidative hair dye). NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 1.0%; 4 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Amino-3-Hydroxypyridine is classified GHS Danger (H301, H302, H311, H315, H319, H335, H373, H411) in the chemicals database but is restricted in EU cosmetics at max 1.0%.
US NotesCIR Expert Panel concluded safe in present practices of use and concentration for oxidative hair dye formulations
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Amino-3-Hydroxypyridine.
Calculate MoS for your specific formulation with the
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Toxicological Studies
10 study endpoints found for 2-Amino-3-Hydroxypyridine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
30 mg/kg bw/day
oral
rat
Subchronic
COSMOS_DB
NOAEL
=0.02 mg/kg bw
oral
rat
dermal absorption
SCCS_vision_codex
NOAEL
=0.02 mg/kg bw
oral
rat
dermal absorption
SCCS_vision_codex
NOAEL
=0.02 mg/kg bw
oral
rat
dermal absorption
SCCS_vision_codex
NOAEL
=0.02 mg/kg bw
oral
rat
dermal absorption
SCCS_vision_codex
NOAEL
=30 mg/kg bw/day
-
-
genotoxicity
SCCS_vision_codex
NOAEL
=30 mg/kg bw
oral
rat
dermal absorption
SCCS_vision_codex
NOAEL
=30 mg/kg bw/day
-
-
genotoxicity
SCCS_vision_codex
NOAEL
=30 mg/kg bw
oral
rat
dermal absorption
SCCS_vision_codex
NOAEL
=30 mg/kg bw/day
-
-
genotoxicity
SCCS_vision_codex
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: unknown
NOAEL: 45 mg/kg
body weight (not specified)
cir
Verdict: unknown
NOAEL: 45 mg/kg body
weight (oral)
cir
Verdict: unknown
NOAEL: 30 mg/kg body weight/day (oral)
cir
Verdict: unknown
NOAEL: 500 mg/kg
body weight (oral)
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-Amino-3-Hydroxypyridine across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for 2-Amino-3-Hydroxypyridine based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Restricted. Max: 산화염모제에 1.0%. 기타 제품에는 사용금지
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes.
JPKR Japan/Korea Cosmetics
Korea (Restricted): max 1.0%
BRIN Brazil/India Cosmetics
India: Restricted
Additional Jurisdictional Restrictions (2)
Jurisdiction
Status
Max %
Product Type
CN
permitted_hair_dye
1
Oxidative hair dye products
BR
permitted_hair_dye
-
Oxidative hair dye
Additional Ingredient Properties
2 property records from structured ingredient metadata.
Public NOAEL study rows linked to 2-Amino-3-Hydroxypyridine by CAS number or substance name.
Studies
19
Lowest NOAEL
0.02
Highest NOAEL
45
Units vary across source rows: mg/kg bw/day, mg/kg bw
COSMOS_DBToxValDB_ECHA_IUCLIDSCCS_vision_codex
Known Synonyms
EINECS 240-886-8UNII-P8740PEW4B
Chemical Function
Dye
Regulatory Lists
Europe; Personal care - hair coloringEurope; Personal care; restricted
Australian Status
AICIS status:listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCEChEMBL / DrugCentral / FAERSDB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
2-Amino-3-Hydroxypyridine has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is 2-Amino-3-Hydroxypyridine allowed in the EU?
2-Amino-3-Hydroxypyridine EU regulatory status: restricted. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Amino-3-Hydroxypyridine do in cosmetics?
2-Amino-3-Hydroxypyridine functions as: Hair Dyeing (oxidative hair dye). It is classified as a cosmetic ingredient in our database. CAS number: 16867-03-1.
What is the NOAEL for 2-Amino-3-Hydroxypyridine?
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-3-Hydroxypyridine is 30 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is 2-Amino-3-Hydroxypyridine used outside cosmetics?
2-Amino-3-Hydroxypyridine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Amino-3-Hydroxypyridine have different safety status in cosmetics vs industrial chemicals?
2-Amino-3-Hydroxypyridine is classified GHS Danger (H301, H302, H311, H315, H319, H335, H373, H411) in the chemicals database but is restricted in EU cosmetics at max 1.0%.
Compliance Tools
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