What is the NOAEL for Eosin?
Eosin has 16 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Eosin
Also known as: EINECS 241-409-6, Eosine Extra Yellowish, Fenazo Eoxine XG, Japan Red 103, Japan Red 230-1 (+15 more)
CAS 17372-87-1
Eosin (CAS 17372-87-1) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Eosin is classified GHS CMR hazard (H319, H341) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Eosin
CAS Number
17372-87-1
DTXSID
DTXSID0025234
Molecular Formula
C20H8Br4O5.2Na
InChI Key
LSMXXHPAEZLILP-UHFFFAOYSA-L
Monoisotopic Mass
689.690062
Synonyms
EINECS 241-409-6Eosine Extra YellowishFenazo Eoxine XGJapan Red 103Japan Red 230-1Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, 2Na2,4,5,7-Tetrabromofluorescein2',4',5',7'-Tetrabromofluorescein disodium saltCerven kysela 87Eosin gelblichUNII-TDQ283MPCW2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9-'-(9H)xanthen)-3-one, disodium salt
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
10 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - body paint - tattoo ink; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 22.10533985 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 27.90394502 | uM | ACC | - | - | NTP_ICE_endocrine |
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 1678RKX8RT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1678RKX8RT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1678RKX8RT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1678RKX8RT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TDQ283MPCW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TDQ283MPCW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TDQ283MPCW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TDQ283MPCW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0524 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0465 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.169 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =1500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate | 241-409-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
EOSIN Y SODIUM
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Eosin?
Eosin appears on 8 regulatory/inventory lists including Arts and crafts/Office supplies - body paint - tattoo ink; Europe, children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 5 more. Source: EPA CPDat.
Is Eosin used in cosmetics?
Yes, Eosin is also indexed as a cosmetic ingredient under the name Eosin Y (D&C Red No. 22). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Eosin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Eosin have different safety status in cosmetics vs industrial chemicals?
Eosin is classified GHS CMR hazard (H319, H341) in the chemicals database but is allowed in EU cosmetics.
Is Eosin used outside industrial chemicals?
Eosin also appears in cosmetics, pharmaceutical, food safety databases.