Moderate Colorant

Eosin Y (D&C Red No. 22)

INCI: CI 45380

CAS Number
17372-87-1
Function
Colorant (red/fluorescent pink), Hair dyeing
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Permanently listed under 21 CFR 74.1322 (drugs) and 74.2322 (cosmetics). All batches must be FDA-certified per 21 CFR Part 80. Not permitted in eye area products. CIR deferred to FDA.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CAS 17372-87-1. EU: Permitted under Annex IV EC 1223/2009 for all cosmetics except eye-area products; impurity limits apply. US: Permanently listed under 21 CFR 74.2322 with required batch certification; prohibited in eye area products.

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Concern Level: Moderate

Regulatory Flags

batch-certification-required eye-area-prohibited photosensitizer contact-dermatitis-reported impurity-driven-sensitization cir-deferred-to-fda color-additive eu_children_restricted

Frequently Asked Questions

Is Eosin Y (D&C Red No. 22) safe in cosmetics?

CAS 17372-87-1. EU: Permitted under Annex IV EC 1223/2009 for all cosmetics except eye-area products; impurity limits apply. US: Permanently listed under 21 CFR 74.2322 with required batch certification; prohibited in eye area products. The EU classifies Eosin Y (D&C Red No. 22) as "permitted". Safety rating: MODERATE.

Is Eosin Y (D&C Red No. 22) allowed in the EU?

Eosin Y (D&C Red No. 22) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Eosin Y (D&C Red No. 22) do in cosmetics?

Eosin Y (D&C Red No. 22) functions as: Colorant (red/fluorescent pink), Hair dyeing. It is classified as a Colorant in our database. CAS number: 17372-87-1.

What is the Margin of Safety for Eosin Y (D&C Red No. 22)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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