Is Eosin Y (D&C Red No. 22) safe in cosmetics?
Eosin Y (D&C Red No. 22) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
Eosin Y (D&C Red No. 22)
Also known as: EINECS 241-409-6, Eosine Extra Yellowish, Fenazo Eoxine XG, Japan Red 103, Japan Red 230-1 (+14 more)
INCI: CI 45380
Eosin Y (D&C Red No. 22) (CAS 17372-87-1) is a cosmetic colorant functioning as Colorant (red/fluorescent pink), Hair dyeing. Reported NOAEL =1500 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 17372-87-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Eosin Y (D&C Red No. 22) is classified GHS CMR hazard (H319, H341) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant (red/fluorescent pink), Hair dyeing
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
disodium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate
InChIKey
SEACYXSIPDVVMV-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Permanently listed under 21 CFR 74.1322 (drugs) and 74.2322 (cosmetics). All batches must be FDA-certified per 21 CFR Part 80. Not permitted in eye area products. CIR deferred to FDA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Eosin Y (D&C Red No. 22).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Eosin Y (D&C Red No. 22). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
colorant
{"Common_Name": "D&C Orange No. 5", "Chemical_Name": "Dibromofluorescein", "CAS_Number": "596-03-2", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "External use only", "Max_Concentration_%": "No limit", "EU_Status": "Not approved", "US_FDA_Status": "Approved 21 CFR 74.1255", "Notes": "Fluorescent orange, US only"}
colorant_formulator
{"ci_number": "45380", "ci_name": "Pigment Red 90", "color_category": "red", "color_hex_code": "#C71585", "natural_or_synthetic": "synthetic", "organic_or_inorganic": "organic", "lake_or_dye": "pigment", "fda_approved_use": "general", "eu_approved_cosmetic": "yes", "japan_approved": "yes", "china_approved": "yes", "coverage_opacity": "transparent", "tinting_strength": "high", "lightfastness_rating…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
CI PIGMENT RED 90 | 1964 | NMRS 38/TRS 309-JECFA 8/22
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Eosin Y (D&C Red No. 22).
Regulatory Flags
batch-certification-required
eye-area-prohibited
photosensitizer
contact-dermatitis-reported
impurity-driven-sensitization
cir-deferred-to-fda
color-additive
eu_children_restricted
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Eosin Y (D&C Red No. 22) by CAS number or substance name.
Studies
1
Lowest NOAEL
1500 mg/kg bw/day
Highest NOAEL
1500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 241-409-6
Eosine Extra Yellowish
Fenazo Eoxine XG
Japan Red 103
Japan Red 230-1
Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, 2Na
2,4,5,7-Tetrabromofluorescein
2',4',5',7'-Tetrabromofluorescein disodium salt
Cerven kysela 87
Eosin gelblich
UNII-TDQ283MPCW
2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9-'-(9H)xanthen)-3-one, disodium salt
C.I. 45380
CI 45380 (Na salt)
D and C Red No. 22
Eosin Y ws
water soluble eosin
water-soluble eosin
eosin YS dye
Chemical Function
Dye
Regulatory Lists
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care
children; Europe; Personal care
pharmaceutical
Personal care
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
Canada; consumer_product; Substances in Products - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EOSIN Y SODIUM
ChEMBL ID
CHEMBL411675
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
D&C Red 22 (Eosin Y)
Food Category
colorant
Frequently Asked Questions
Is Eosin Y (D&C Red No. 22) allowed in the EU?
Eosin Y (D&C Red No. 22) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Eosin Y (D&C Red No. 22) do in cosmetics?
Eosin Y (D&C Red No. 22) functions as: Colorant (red/fluorescent pink), Hair dyeing. It is classified as a Colorant in our database. CAS number: 17372-87-1.
What is the NOAEL for Eosin Y (D&C Red No. 22)?
The NOAEL (No Observed Adverse Effect Level) for Eosin Y (D&C Red No. 22) is =1500 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Eosin Y (D&C Red No. 22) used outside cosmetics?
Eosin Y (D&C Red No. 22) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Eosin Y (D&C Red No. 22) have different safety status in cosmetics vs industrial chemicals?
Eosin Y (D&C Red No. 22) is classified GHS CMR hazard (H319, H341) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Eosin Y (D&C Red No. 22) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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