What is the NOAEL for 3-(4-tert-Butylphenyl)propanal?
3-(4-tert-Butylphenyl)propanal has 18 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-(4-tert-Butylphenyl)propanal
Also known as: Benzenepropanal, 4-(1,1-dimethylethyl)-, Bourgeonal, BRN 2439407, p-tert-Butyldihydrocinnamaldehyde, p-tert-Butylhydrocinnamic aldehyde (+3 more)
CAS 18127-01-0
3-(4-tert-Butylphenyl)propanal (CAS 18127-01-0) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) →
Cross-Vertical Regulatory Divergence
3-(4-tert-Butylphenyl)propanal is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H315, H317, H361, H373, H411, H412).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
3-(4-tert-Butylphenyl)propanal
CAS Number
18127-01-0
DTXSID
DTXSID6044808
Molecular Formula
C13H18O
InChI Key
FZJUFJKVIYFBSY-UHFFFAOYSA-N
Monoisotopic Mass
190.135765
Synonyms
Benzenepropanal, 4-(1,1-dimethylethyl)-BourgeonalBRN 2439407p-tert-Butyldihydrocinnamaldehydep-tert-Butylhydrocinnamic aldehyde4-(1,1-Dimethylethyl)benzenepropanalEINECS 242-016-2UNII-H3XVS6E70V
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| consumer_product | P&G | Proctor & Gamble |
| Europe; Personal care; restricted | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 27.16 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 46.4 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =0.22 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =0.308 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| H3XVS6E70V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H3XVS6E70V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H3XVS6E70V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H3XVS6E70V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 67.73 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.74 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 4050 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-(4-tert-butylphenyl)propionaldehyde | 242-016-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183621
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 3-(4-tert-Butylphenyl)propanal?
3-(4-tert-Butylphenyl)propanal appears on 3 regulatory/inventory lists including consumer_product, Europe; Personal care; restricted, IFRA Transparency. Source: EPA CPDat.
Is 3-(4-tert-Butylphenyl)propanal used in cosmetics?
Yes, 3-(4-tert-Butylphenyl)propanal is also indexed as a cosmetic ingredient under the name 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-(4-tert-Butylphenyl)propanal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 3-(4-tert-Butylphenyl)propanal have different safety status in cosmetics vs industrial chemicals?
3-(4-tert-Butylphenyl)propanal is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H315, H317, H361, H373, H411, H412).
Is 3-(4-tert-Butylphenyl)propanal used outside industrial chemicals?
3-(4-tert-Butylphenyl)propanal also appears in cosmetics, pharmaceutical databases.