Moderate Cosmetic Ingredient Sensitization Data

4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal)

INCI: BUTYLPHENYL METHYLPROPIONAL

CAS Number
18127-01-0
Function
Fragrance (lily-of-the-valley note)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no specific FDA restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.5%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: ESSCA/SCCS (banned 2022)

Expert Verdict

Prohibited in EU due to health hazards including acute toxicity (H301), skin irritation (H315), allergic sensitization (H317), suspected reproductive toxicity (H361), and organ damage with repeated exposure (H373). Metabolizes to 4-tert-butylbenzoic acid, which is linked to testicular toxicity in animal studies.

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Concern Level: High

Regulatory Flags

fragrance-component ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) safe in cosmetics?

Prohibited in EU due to health hazards including acute toxicity (H301), skin irritation (H315), allergic sensitization (H317), suspected reproductive toxicity (H361), and organ damage with repeated exposure (H373). Metabolizes to 4-tert-butylbenzoic acid, which is linked to testicular toxicity in animal studies. The EU classifies 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) as "prohibited". Safety rating: MODERATE.

Is 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) allowed in the EU?

4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) do in cosmetics?

4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) functions as: Fragrance (lily-of-the-valley note). It is classified as a cosmetic ingredient in our database. CAS number: 18127-01-0.

What is the Margin of Safety for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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