Also known as: Benzenepropanal, 4-(1,1-dimethylethyl)-, Bourgeonal, BRN 2439407, p-tert-Butyldihydrocinnamaldehyde, p-tert-Butylhydrocinnamic aldehyde (+3 more)
INCI: BUTYLPHENYL METHYLPROPIONAL
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) (CAS 18127-01-0) is a cosmetic cosmetic ingredient functioning as Fragrance (lily-of-the-valley note). Reported NOAEL =5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 18127-01-0 →
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H315, H317, H361, H373, H411, H412).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal).
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =25 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Contact sensitization data for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) based on clinical patch test studies and IFRA standards.
Source: ESSCA/SCCS (banned 2022)
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: Report to RIFM by Givaudan (RIFM DB#41055); DPRA: Hoffmann et al., 2018; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: No reference provided in NICEATM database; HPPT: [357] Epstein WL (1980): Report to RIFM, 25 June, unpublished.
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 4050 | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal).
Public NOAEL study rows linked to 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) functions as: Fragrance (lily-of-the-valley note). It is classified as a cosmetic ingredient in our database. CAS number: 18127-01-0.
The NOAEL (No Observed Adverse Effect Level) for 4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) is =5 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H315, H317, H361, H373, H411, H412).
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