NOAEL Data REACH Registered Cosmetic Ingredient

Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl-

Also known as: BRN 2318488, EINECS 217-420-7, 4,4',4''-(1-Methyl-1-propanyl-3-ylidene)tris(2-(1,1-dimethylethyl)-5-methylphenol), Topanol CA, Trisalkofen BMB (+2 more)

CAS 1843-03-4

Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- (CAS 1843-03-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Tributylcresylbutane →

SOURCE noael studies public
NOAEL studies
6
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl-
CAS Number
1843-03-4
DTXSID
DTXSID0038883
Molecular Formula
C37H52O3
InChI Key
PRWJPWSKLXYEPD-UHFFFAOYSA-N
Monoisotopic Mass
544.391646
Synonyms
BRN 2318488EINECS 217-420-74,4',4''-(1-Methyl-1-propanyl-3-ylidene)tris(2-(1,1-dimethylethyl)-5-methylphenol)Topanol CATrisalkofen BMB1,1,3-Tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butaneUNII-BF6E9O0XJN

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records
SolventFilm formerPlasticizerAntioxidant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
Europe; plastic_additiveEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 6 of 6 studies
ValueUnitEndpointRouteSpeciesSource
=3.53mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
BF6E9O0XJNUNIIFDA UNII substance identifier--openFDA substances
BF6E9O0XJNUNIIFDA UNII substance identifier--openFDA substances
BF6E9O0XJNUNIIFDA UNII substance identifier--openFDA substances
BF6E9O0XJNUNIIFDA UNII substance identifier--openFDA substances
=48mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID

Showing 6 of 6 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered4,4',4''-(1-methylpropanyl-3-ylidene)tris[6-tert-butyl-m-cresol]217-420-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl-?

Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- has 6 NOAEL studies in the database. The lowest reported value is 3.53 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl-?

Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- appears on 3 regulatory/inventory lists including Indirect additives food contact (10/2018), Europe; plastic_additive, drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.

Is Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- used in cosmetics?

Yes, Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- is also indexed as a cosmetic ingredient under the name Tributylcresylbutane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- used outside industrial chemicals?

Phenol, 4,4',4''-(1-methyl-1-propanyl-3-ylidene)tris 2-(1,1-dimethylethyl)-5-methyl- also appears in cosmetics databases.