Is Tributylcresylbutane safe in cosmetics?
Tributylcresylbutane has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Tributylcresylbutane
Also known as: BRN 2318488, EINECS 217-420-7, 4,4',4''-(1-Methyl-1-propanyl-3-ylidene)tris(2-(1,1-dimethylethyl)-5-methylphenol), Topanol CA, Trisalkofen BMB (+2 more)
INCI: TRIBUTYLCRESYLBUTANE
Tributylcresylbutane (CAS 1843-03-4) is a cosmetic cosmetic ingredient functioning as Film-forming, plasticizer, solvent. Reported NOAEL =48 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1843-03-4 →
Auto-generated CPSR Part A draft with source citations
Function
Film-forming, plasticizer, solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-[4,4-bis(5-tert-butyl-4-hydroxy-2-methylphenyl)butan-2-yl]-2-tert-butyl-5-methylphenol
InChIKey
PRWJPWSKLXYEPD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tributylcresylbutane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Tributylcresylbutane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =48 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Film former
Plasticizer
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Tributylcresylbutane.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tributylcresylbutane by CAS number or substance name.
Studies
1
Lowest NOAEL
48 mg/kg bw/day
Highest NOAEL
48 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
BRN 2318488
EINECS 217-420-7
4,4',4''-(1-Methyl-1-propanyl-3-ylidene)tris(2-(1,1-dimethylethyl)-5-methylphenol)
Topanol CA
Trisalkofen BMB
1,1,3-Tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane
UNII-BF6E9O0XJN
Chemical Function
Solvent
Film former
Plasticizer
Antioxidant
Regulatory Lists
Indirect additives food contact (10/2018)
Europe; plastic_additive
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Tributylcresylbutane allowed in the EU?
Tributylcresylbutane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tributylcresylbutane do in cosmetics?
Tributylcresylbutane functions as: Film-forming, plasticizer, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 1843-03-4.
What is the NOAEL for Tributylcresylbutane?
The NOAEL (No Observed Adverse Effect Level) for Tributylcresylbutane is =48 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Tributylcresylbutane used outside cosmetics?
Tributylcresylbutane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tributylcresylbutane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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