NOAEL Data REACH Registered Cosmetic Ingredient

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

Also known as: 2,4,11,13-Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate, D-Gluconic acid, compd. with 1,1′-hexamethylenebis[5-(p-chlorophenyl)biguanide] (2:1), D-Gluconic acid, compd. with N,N′′-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1), 1,1′-Hexamethylenebis[5-(p-chlorophenyl)biguanide] digluconate, Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, digluconate (+15 more)

CAS 18472-51-0

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) (CAS 18472-51-0) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Chlorhexidine Digluconate →

Cross-Vertical Regulatory Divergence

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) is classified GHS Danger (H302, H318, H400, H410, H317, H334) in the chemicals database but is restricted in EU cosmetics at max 0.3%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

CAS Number

18472-51-0

DTXSID

DTXSID5034519

Molecular Formula

C22H30Cl2N10.2C6H12O7

InChI Key

YZIYKJHYYHPJIB-UUPCJSQJSA-N

Monoisotopic Mass

896.319802

Synonyms

2,4,11,13-Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconateD-Gluconic acid, compd. with 1,1′-hexamethylenebis[5-(p-chlorophenyl)biguanide] (2:1)D-Gluconic acid, compd. with N,N′′-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)1,1′-Hexamethylenebis[5-(p-chlorophenyl)biguanide] digluconateBiguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, digluconate1,6-Bis(5-(p-chlorophenyl)biguandino)hexane digluconateCaswell No. 481GEINECS 242-354-0EPA Pesticide Chemical Code 0455041,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) gluconate1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconateOrahexal

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 13 records

PreservativeBiocideFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records

List	Keyword	Source
Europe; Personal care - body hygiene - hand soap	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
IFRA Transparency	IFRA	IFRA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
=0.36	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
MOR84MUD8E	UNII	FDA UNII substance identifier	-	-	openFDA substances
MOR84MUD8E	UNII	FDA UNII substance identifier	-	-	openFDA substances
MOR84MUD8E	UNII	FDA UNII substance identifier	-	-	openFDA substances
MOR84MUD8E	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)	242-354-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.3%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHLORHEXIDINE GLUCONATE

ChEMBL Phase

Adverse Events

1999

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)?

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) has 5 NOAEL studies in the database. The lowest reported value is 0.36 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)?

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) appears on 4 regulatory/inventory lists including Europe; Personal care - body hygiene - hand soap, active_ingredient; Pesticides, IFRA Transparency, and 1 more. Source: EPA CPDat.

Is D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) used in cosmetics?

Yes, D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) is also indexed as a cosmetic ingredient under the name Chlorhexidine Digluconate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) have different safety status in cosmetics vs industrial chemicals?

Is D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) used outside industrial chemicals?

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) also appears in cosmetics, pharmaceutical databases.