Chlorhexidine Digluconate
INCI: CHLORHEXIDINE DIGLUCONATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Chlorhexidine Digluconate based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; NACDG
Dermal Penetration Profile
Skin absorption and penetration characteristics of Chlorhexidine Digluconate, relevant to systemic exposure and MoS calculations.
Source: SCCS Opinion
Expert Verdict
Chlorhexidine digluconate is a restricted preservative in the EU (Annex V, max 0.3% as chlorhexidine) with regulatory concerns regarding environmental persistence and potential endocrine disruption. In the US, cosmetic use is permitted per CIR at concentrations up to 0.20%, though it does not qualify for OTC antiseptic monograph use.
Regulatory Flags
Frequently Asked Questions
Is Chlorhexidine Digluconate safe in cosmetics?
Chlorhexidine digluconate is a restricted preservative in the EU (Annex V, max 0.3% as chlorhexidine) with regulatory concerns regarding environmental persistence and potential endocrine disruption. In the US, cosmetic use is permitted per CIR at concentrations up to 0.20%, though it does not qualify for OTC antiseptic monograph use. The EU classifies Chlorhexidine Digluconate as "restricted". Safety rating: MODERATE.
Is Chlorhexidine Digluconate allowed in the EU?
Chlorhexidine Digluconate EU regulatory status: restricted. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does Chlorhexidine Digluconate do in cosmetics?
Chlorhexidine Digluconate functions as: preservative; antimicrobial; antifungal. It is classified as a Preservative in our database. CAS number: 18472-51-0.
What is the Margin of Safety for Chlorhexidine Digluconate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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