NOAEL Data REACH Registered Cosmetic Ingredient

D&C Red 28

Also known as: Phloxine B, Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium salt, EINECS 242-355-6, Food Dye Red No. 104, Japan Red 104 (+2 more)

CAS 18472-87-2

D&C Red 28 (CAS 18472-87-2) is a chemical substance. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Red 28 Lake (CI 45410)__ →

SOURCE noael studies public
NOAEL studies
48
SOURCE chemical inventory jurisdictions
Regulatory lists
13
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
D&C Red 28
CAS Number
18472-87-2
DTXSID
DTXSID1031090
Molecular Formula
C20H6Br4Cl4O5.2Na
InChI Key
GFSNXSXKYPCYDQ-UHFFFAOYSA-L
Monoisotopic Mass
827.549823
Synonyms
Phloxine BFluorescein, 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium saltEINECS 242-355-6Food Dye Red No. 104Japan Red 104Japan Red 104-1Red No. 104-1

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 13 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bubble bathDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - dental care - toothpasteDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
Personal careFDAUnited States Food and Drug Administration (FDA)
Europe; Personal care; restrictedEuropean CommissionCosIng
inert_ingredient; non_food_use; PesticidesEPACPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 48 of 48 studies
ValueUnitEndpointRouteSpeciesSource
=15.1mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
71unitlessDraize rabbit irritation scoreOcularRabbitNTP_ICE_eye_irritation
1unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
767IP0Y5NHUNIIFDA UNII substance identifier--openFDA substances
767IP0Y5NHUNIIFDA UNII substance identifier--openFDA substances
767IP0Y5NHUNIIFDA UNII substance identifier--openFDA substances
767IP0Y5NHUNIIFDA UNII substance identifier--openFDA substances
2unitlessGHS ClassificationOcularRabbitNTP_ICE_eye_irritation
0.74%/secIntensityOcular-NTP_ICE_eye_irritation
10mg/kg bw/dayLOAELoralratCOSMOS_DB
=2000mg/kg bw/dayLOAELoralMouseToxValDB_ECHA_IUCLID
=10mg/kg bw/dayLOELoralMouseToxValDB_ECOTOX
-sLag timeOcular-NTP_ICE_eye_irritation
=0.14mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.14mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.14mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.14mg/kg bw/dayNOAELoralratSCCS_vision_codex
=50mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=50mg/kg bw/dayNOAEL--SCCS_vision_codex
=50mg/kg bw/dayNOAELdermal-SCCNFP_vision_codex
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=50mg/kg bw/dayNOAEL--SCCS_vision_codex
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=50mg/kg bw/dayNOAEL--SCCS_vision_codex
=50mg/kg bw/dayNOAELdermal-SCCNFP_vision_codex
=50mg/kg bw/dayNOAELdermal-SCCNFP_vision_codex
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=50mg/kg bw/dayNOAEL--SCCS_vision_codex
=50mg/kg bw/dayNOAELdermal-SCCNFP_vision_codex
=250mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=500mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=920mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=2000mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=1mg/kg bw/dayNOELoralMouseToxValDB_ECOTOX
82%Plateau levelOcular-NTP_ICE_eye_irritation
50mg/kg bw/daydevelopmental toxicity--UnifiedCodex:SCCNFP:beta.noael_studies
50mg/kg bw/dgenotoxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/dgenotoxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/dayirritation-humanUnifiedCodex:SCCNFP:beta.noael_studies
=0.14mg/kg bw/dayrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/dayrepeated dose toxicitydermal-UnifiedCodex:SCCNFP:beta.noael_studies
50mg/kg bw/dayrepeated dose toxicitydermalrabbitUnifiedCodex:SCCNFP:beta.noael_studies
=50mg/kg bw/dayrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/dayrepeated dose toxicitydermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/dayrepeated dose toxicitydermal-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/dayreproductive toxicity-pigUnifiedCodex:SCCNFP:beta.noael_studies
50mg/kg bw/dayreproductive toxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 48 of 48 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered3,4,5,6-tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid242-355-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1465/1227 March 2012safe0.6%sensitisation potential not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.4%
Category
colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL61441
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for D&C Red 28?

D&C Red 28 has 48 NOAEL studies in the database. The lowest reported value is 1 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.

What regulatory lists include D&C Red 28?

D&C Red 28 appears on 10 regulatory/inventory lists including Europe; Personal care - hair coloring, children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bubble bath, and 7 more. Source: EPA CPDat.

Is D&C Red 28 used in cosmetics?

Yes, D&C Red 28 is also indexed as a cosmetic ingredient under the name Red 28 Lake (CI 45410)__. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for D&C Red 28 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is D&C Red 28 used outside industrial chemicals?

D&C Red 28 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.