What is the NOAEL for Chromium (VI) ion?
Chromium (VI) ion has 36 NOAEL studies in the database. The lowest reported value is 0.000005 mg/m3 via inhalation in Human. Source: ToxValDB_ATSDR_MRLs.
NOAEL Data
IARC Group 1
Cosmetic Ingredient
Chromium (VI) ion
Also known as: Hexavalent chromium ion, Cr6+, CHROMIUM (VI), Hexavalent chromium, Chromium (cr(sup 6+)) (+12 more)
CAS 18540-29-9
Chromium (VI) ion (CAS 18540-29-9) is a chemical substance; key hazard signal: IARC Group 1. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC.
SOURCE
noael studies public
NOAEL studies
36
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Chromium (VI) ion
CAS Number
18540-29-9
DTXSID
DTXSID7023982
Molecular Formula
Cr
InChI Key
JOPOVCBBYLSVDA-UHFFFAOYSA-N
Monoisotopic Mass
51.940506
Synonyms
Hexavalent chromium ionCr6+CHROMIUM (VI)Hexavalent chromiumChromium (cr(sup 6+))Chromium(6+) ionChromium(6+) ionsChromium(6+)ionChromium(6+)ionsChromium(VI) ionsNCI-C04273Chromium hexavalent ion
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 1 | Carcinogenic to humans | 2009 | Sup 7, 49, 100C |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Degradant/impurityNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Europe; Other direct contact consumer goods - apparel | - | Danish EPA |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 36 of 36 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.016 | mg/m3 | BMCL | inhalation | Rat | ToxValDB_ATSDR_MRLs |
| =0.034 | mg/m3 | BMCL (10 HEC) | inhalation | Rat | ToxValDB_IRIS |
| =0.01 | mg/m3 | BMCL (HEC) | inhalation | Rat | ToxValDB_ATSDR_MRLs |
| =0.2 | mg/kg bw/day | BMDL (05) | oral | Rat | ToxValDB_EFSA |
| =0.09 | mg chromium(VI)/kg-day | BMDL (10) | oral | Mouse | ToxValDB_ATSDR_MRLs |
| =0.11 | mg/kg bw/day | BMDL (10) | oral | Mouse | ToxValDB_EFSA |
| =1 | mg/kg bw/day | BMDL (10) | oral | Mouse | ToxValDB_EFSA |
| =0.52 | mg chromium(VI)/kg-day | BMDL (2 SD) | oral | Rat | ToxValDB_ATSDR_MRLs |
| =0.0911 | mg/mg-day | HED | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| 1 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 1 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 1 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 1 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.012 | ug/m3 | Inhalation risk unit | Inhalation | - | NTP_ICE_cancer |
| =0.002 | mg/m3 | LOAEL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =0.002 | mg/m3 | LOAEL | inhalation | Human (M/F) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| =0.0034 | mg/m^3 | LOAEL | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =13.14 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_DOE_Wildlife_Benchmarks |
| =0.000714 | mg/m3 | LOAEL (ADJ) | inhalation | Human | ToxValDB_IRIS |
| =0.000005 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =0.000005 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =0.0003 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =0.0003 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =0.0009 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.0009 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.005 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.005 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =3.28 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_DOE_Wildlife_Benchmarks |
| =25 | mg/L | NOAEL | oral | Rat | ToxValDB_IRIS |
| =2.5 | mg/kg bw/day | NOAEL (ADJ) | oral | Rat | ToxValDB_IRIS |
| =0.000008 | mg/m3 | RfC | inhalation | Human | ToxValDB_IRIS |
| =0.00003 | mg/m^3 | RfC | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =0.0001 | mg/m3 | RfC | inhalation | Human | ToxValDB_IRIS |
| =0.0009 | mg/kg/day | RfD | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =0.003 | mg/kg bw/day | RfD | oral | Human | ToxValDB_IRIS |
| =0.0031 | mg CrVI/kg-day | RfD | oral | Human | ToxValDB_TX_TCEQ |
Showing 36 of 36 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0.003 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Chromium (VI) ion?
Chromium (VI) ion appears on 3 regulatory/inventory lists including banned; Europe; Personal care, Europe; Other direct contact consumer goods - apparel, detected; drinking_water; MN Chemical Screening. Source: EPA CPDat.
Is Chromium (VI) ion a carcinogen according to IARC?
Chromium (VI) ion is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Chromium (VI) ion used in cosmetics?
Yes, Chromium (VI) ion is also indexed as a cosmetic ingredient under the name MENADIONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Chromium (VI) ion come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Chromium (VI) ion used outside industrial chemicals?
Chromium (VI) ion also appears in cosmetics, food safety, cannabis databases.