Is MENADIONE safe in cosmetics?
MENADIONE has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
MENADIONE
Also known as: Hexavalent chromium ion, Cr6+, CHROMIUM (VI), Hexavalent chromium, Chromium (cr(sup 6+)) (+12 more)
MENADIONE (CAS 18540-29-9) is a cosmetic cosmetic ingredient functioning as Insufficient Data. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 18540-29-9 →
Function
Insufficient Data
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for MENADIONE.
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
1
Volume
Sup 7, 49, 100C
Evaluation Year
2009
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: heavy metal
Receptor targets: GR, AR
LOEC: 1 µM
EU status: banned (Annex II)
modulator (GR); antagonist (AR)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | banned | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Degradant/impurity
No specific technical function
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for MENADIONE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Hexavalent chromium ion
Cr6+
CHROMIUM (VI)
Hexavalent chromium
Chromium (cr(sup 6+))
Chromium(6+) ion
Chromium(6+) ions
Chromium(6+)ion
Chromium(6+)ions
Chromium(VI) ions
NCI-C04273
Chromium hexavalent ion
Chromium ion (6+)
Cr(6+)
chromium(VI)
Hexavalent Chromium (Cr6+)
Cr+6
Chemical Function
Degradant/impurity
No specific technical function
Regulatory Lists
banned; Europe; Personal care
Europe; Other direct contact consumer goods - apparel
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Chromium VI
ADI
0.003 mg/kg bw
Food Category
contaminants
Frequently Asked Questions
Is MENADIONE allowed in the EU?
MENADIONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does MENADIONE do in cosmetics?
MENADIONE functions as: Insufficient Data. It is classified as a cosmetic ingredient in our database. CAS number: 18540-29-9.
Is MENADIONE used outside cosmetics?
MENADIONE also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check MENADIONE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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