What is the NOAEL for Dihexyl (2E)-2-butenedioate?
Dihexyl (2E)-2-butenedioate has 8 NOAEL studies in the database. The lowest reported value is 6B3O343SS2 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dihexyl (2E)-2-butenedioate
Also known as: Dihexyl fumarate, 2-Butenedioic acid, dihexyl ester, (2E)-, 2-Butenedioic acid (2E)-, 1,4-dihexyl ester, 2-Butenedioic acid (2E)-, dihexyl ester, 2-Butenedioic acid (E)-, dihexyl ester (+2 more)
CAS 19139-31-2
Dihexyl (2E)-2-butenedioate (CAS 19139-31-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dihexyl (2E)-2-butenedioate is prohibited in EU cosmetics but has active industrial GHS classifications.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Dihexyl (2E)-2-butenedioate
CAS Number
19139-31-2
DTXSID
DTXSID00893393
Molecular Formula
C16H28O4
InChI Key
QMCVOSQFZZCSLN-VAWYXSNFSA-N
Monoisotopic Mass
284.198759
Synonyms
Dihexyl fumarate2-Butenedioic acid, dihexyl ester, (2E)-2-Butenedioic acid (2E)-, 1,4-dihexyl ester2-Butenedioic acid (2E)-, dihexyl ester2-Butenedioic acid (E)-, dihexyl esterFumaric acid, dihexyl esterEINECS No.: 242-833-4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6B3O343SS2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6B3O343SS2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6B3O343SS2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6B3O343SS2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dihexyl fumarate | 242-833-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3247954
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Dihexyl (2E)-2-butenedioate?
Dihexyl (2E)-2-butenedioate appears on 3 regulatory/inventory lists including IFRA Transparency, consumer_product, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Dihexyl (2E)-2-butenedioate used in cosmetics?
Yes, Dihexyl (2E)-2-butenedioate is also indexed as a cosmetic ingredient under the name Dihexyl Fumarate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dihexyl (2E)-2-butenedioate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dihexyl (2E)-2-butenedioate have different safety status in cosmetics vs industrial chemicals?
Dihexyl (2E)-2-butenedioate is prohibited in EU cosmetics but has active industrial GHS classifications.
Is Dihexyl (2E)-2-butenedioate used outside industrial chemicals?
Dihexyl (2E)-2-butenedioate also appears in cosmetics, pharmaceutical databases.