Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dihexyl Fumarate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Fumarate ester sensitization concern — although diisostearyl fumarate was non-sensitizing, the shorter C6 chain of dihexyl fumarate is closer to the problematic dimethyl/diethyl range; HRIPT or LLNA data recommended before CPSR sign-off; odor profile: herbal, fresh, floral
Regulatory Flags
Frequently Asked Questions
Is Dihexyl Fumarate safe in cosmetics?
Fumarate ester sensitization concern — although diisostearyl fumarate was non-sensitizing, the shorter C6 chain of dihexyl fumarate is closer to the problematic dimethyl/diethyl range; HRIPT or LLNA data recommended before CPSR sign-off; odor profile: herbal, fresh, floral The EU classifies Dihexyl Fumarate as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Dihexyl Fumarate allowed in the EU?
Dihexyl Fumarate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihexyl Fumarate do in cosmetics?
Dihexyl Fumarate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 19139-31-2.
What is the Margin of Safety for Dihexyl Fumarate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihexyl Fumarate?
The NOAEL (No Observed Adverse Effect Level) for Dihexyl Fumarate is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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