NOAEL Data Cosmetic Ingredient

1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone

Also known as: 2(1H)-Pyridinone, 5,6-dihydro-1-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (E)-, Piperlongumine

CAS 20069-09-4

1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone (CAS 20069-09-4) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Piperlongumine →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone
CAS Number
20069-09-4
DTXSID
DTXSID801029762
Molecular Formula
C17H19NO5
InChI Key
VABYUUZNAVQNPG-BQYQJAHWSA-N
Monoisotopic Mass
317.126323
Synonyms
2(1H)-Pyridinone, 5,6-dihydro-1-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (E)-Piperlongumine

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
AntioxidantSoftener and conditionerBleaching agent

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
SGD66V4SVJUNIIFDA UNII substance identifier--openFDA substances
SGD66V4SVJUNIIFDA UNII substance identifier--openFDA substances
SGD66V4SVJUNIIFDA UNII substance identifier--openFDA substances
SGD66V4SVJUNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL PIPLARTINE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
5
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone?

1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone has 4 NOAEL studies in the database. The lowest reported value is SGD66V4SVJ UNII. Source: openFDA substances.

Is 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone used in cosmetics?

Yes, 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone is also indexed as a cosmetic ingredient under the name Piperlongumine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone used outside industrial chemicals?

1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone also appears in cosmetics, pharmaceutical databases.