Regulatory Status
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Safety Data
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Expert Verdict
Contains α,β-unsaturated carbonyl (Michael acceptor) with SCCS structural alert for skin sensitization; selectively induces apoptosis via ROS elevation through electrophilic reactivity with cellular thiols; extremely limited cosmetic safety precedent with no SCCS opinion or CIR review.
Regulatory Flags
Frequently Asked Questions
Is Piperlongumine safe in cosmetics?
Contains α,β-unsaturated carbonyl (Michael acceptor) with SCCS structural alert for skin sensitization; selectively induces apoptosis via ROS elevation through electrophilic reactivity with cellular thiols; extremely limited cosmetic safety precedent with no SCCS opinion or CIR review. The EU classifies Piperlongumine as "permitted". Safety rating: POOR.
Is Piperlongumine allowed in the EU?
Piperlongumine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperlongumine do in cosmetics?
Piperlongumine functions as: Skin conditioning (CosIng); research-stage bioactive. It is classified as a cosmetic ingredient in our database. CAS number: 20069-09-4.
What is the Margin of Safety for Piperlongumine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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