What is the NOAEL for Rosmarinic acid?
Rosmarinic acid has 6 NOAEL studies in the database. The lowest reported value is MQE6XG29YI UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Rosmarinic acid
Also known as: Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-, Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, (αR)-, Cinnamic acid, 3,4-dihydroxy-, 2-ester with 3-(3,4-dihydroxyphenyl)lactic acid, Rosemary acid, Labiatic acid (+14 more)
CAS 20283-92-5
Rosmarinic acid (CAS 20283-92-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Rosmarinic acid is classified GHS Danger (H301, H400) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Rosmarinic acid
CAS Number
20283-92-5
DTXSID
DTXSID20896987
Molecular Formula
C18H16O8
InChI Key
DOUMFZQKYFQNTF-WUTVXBCWSA-N
Monoisotopic Mass
360.084517
Synonyms
Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, (αR)-Cinnamic acid, 3,4-dihydroxy-, 2-ester with 3-(3,4-dihydroxyphenyl)lactic acidRosemary acidLabiatic acidLabiatenic acidBenzenepropanoic acid, α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, [R-(E)]-Rosemaric acidtrans-Rosmarinic acid(αR)-α-[[(2E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acidMamorekku RUH 2Meiji Red Perilla Polyphenol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
AntioxidantHumectant
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| MQE6XG29YI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| MQE6XG29YI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| MQE6XG29YI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| MQE6XG29YI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =300 | mg/kg bw | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 6 of 6 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ROSMARINIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is Rosmarinic acid used in cosmetics?
Yes, Rosmarinic acid is also indexed as a cosmetic ingredient under the name Rosmarinic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Rosmarinic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Rosmarinic acid have different safety status in cosmetics vs industrial chemicals?
Rosmarinic acid is classified GHS Danger (H301, H400) in the chemicals database but is allowed in EU cosmetics.
Is Rosmarinic acid used outside industrial chemicals?
Rosmarinic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.