Is Rosmarinic Acid safe in cosmetics?
Rosmarinic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Rosmarinic Acid
Also known as: Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-, Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, (αR)-, Cinnamic acid, 3,4-dihydroxy-, 2-ester with 3-(3,4-dihydroxyphenyl)lactic acid, Rosemary acid, Labiatic acid (+14 more)
INCI: ROSMARINIC ACID
Rosmarinic Acid (CAS 20283-92-5) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning, anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 20283-92-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Rosmarinic Acid is classified GHS Danger (H301, H400) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant, skin conditioning, anti-inflammatory
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid
InChIKey
DOUMFZQKYFQNTF-WUTVXBCWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; assessed by CIR as safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Rosmarinic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg-day | Rat | oral | subchronic | EFSA |
Additional Ingredient Properties
4 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-inflammatory", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journa…
anti_pollution
{"cas_number": "20283-92-5", "ingredient_class": "Nrf2_activator", "primary_mechanism": "enzyme_induction", "pollution_types_targeted": "PM2_5/ozone", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_…
antioxidant
{"cas_number": "20283-92-5", "antioxidant_class": "polyphenol", "chemical_subclass": "phenolic acid ester", "molecular_weight_daltons": "360.31", "orac_value_umol_te_per_g": "16800", "dpph_radical_scavenging_ic50_ug_per_ml": "18-28", "abts_trolox_equivalent": "1.0", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "high", "lipid_peroxid…
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "recommended", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "anti-inflammatory", "skin_benefit_secondary": "antimic…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Rosmarinic Acid.
Regulatory Flags
natural-origin
Known Synonyms
Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-
Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, (αR)-
Cinnamic acid, 3,4-dihydroxy-, 2-ester with 3-(3,4-dihydroxyphenyl)lactic acid
Rosemary acid
Labiatic acid
Labiatenic acid
Benzenepropanoic acid, α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, [R-(E)]-
Rosemaric acid
trans-Rosmarinic acid
(αR)-α-[[(2E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid
Mamorekku RUH 2
Meiji Red Perilla Polyphenol
NPLC 0542
RM 21A
(2R)-2-[[(2E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]]oxy]-3-(3,4-dihydroxyphenyl)propanoic acid
Rosmarinic Acid 90%
EC No.: 606-487-1
EC No.: 920-030-6
EC No.: 923-388-1
Chemical Function
Antioxidant
Humectant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ROSMARINIC ACID
ChEMBL ID
CHEMBL324842
Frequently Asked Questions
Is Rosmarinic Acid allowed in the EU?
Rosmarinic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Rosmarinic Acid do in cosmetics?
Rosmarinic Acid functions as: Antioxidant, skin conditioning, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 20283-92-5.
Is Rosmarinic Acid used outside cosmetics?
Rosmarinic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Rosmarinic Acid have different safety status in cosmetics vs industrial chemicals?
Rosmarinic Acid is classified GHS Danger (H301, H400) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Rosmarinic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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