NOAEL Data REACH Registered Cosmetic Ingredient

Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

Also known as: Benzenepropanoic acid, 3,​5-​bis(1,​1-​dimethylethyl)​-​4-​hydroxy-​, octadecyl ester, EINECS 218-216-0, Stearyl 3-(4-hydroxy-3,5-di-tert-butyl-4-hydroxyphenyl)propionate, Stearyl beta-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, Octadecyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate (+1 more)

CAS 2082-79-3

Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (CAS 2082-79-3) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE →

SOURCE NOAEL studies
NOAEL studies
30
SOURCE Chemical inventory jurisdictions
Regulatory lists
6
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
CAS Number
2082-79-3
DTXSID
DTXSID8027456
Molecular Formula
C35H62O3
InChI Key
SSDSCDGVMJFTEQ-UHFFFAOYSA-N
Monoisotopic Mass
530.469896
Synonyms
Benzenepropanoic acid, 3,​5-​bis(1,​1-​dimethylethyl)​-​4-​hydroxy-​, octadecyl esterEINECS 218-216-0Stearyl 3-(4-hydroxy-3,5-di-tert-butyl-4-hydroxyphenyl)propionateStearyl beta-(3,5-di-tert-butyl-4-hydroxyphenyl)propionateOctadecyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamateUNII-V88J661G2P

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
FragranceAntioxidantProcessing aids not otherwise specifiedHeat stabilizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
EuropeEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; plastic_additiveEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 30 of 30 studies
ValueUnitEndpointRouteSpeciesSource
=3.6mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
V88J661G2PUNIIFDA UNII substance identifier--openFDA substances
V88J661G2PUNIIFDA UNII substance identifier--openFDA substances
V88J661G2PUNIIFDA UNII substance identifier--openFDA substances
V88J661G2PUNIIFDA UNII substance identifier--openFDA substances
>0.667mg/LLC50Inhalation-NTP ICE acute inhalation
>1.81mg/LLC50Inhalation-NTP ICE acute inhalation
>5000mg/kg bwLD50oralRatNTP ICE acute oral
=500ppmLOAELoralRatToxValDB HPVIS
>0.543mg/LNOAELinhalationRatToxValDB HPVIS
>=30mg/kg bw/dayNOAELoralRatECHA
>=31.5mg/kg bw/dayNOAELoralDogToxValDB HPVIS
~34mg/kg bw/dayNOAELoralDogECHA
<=34.5mg/kg bw/dayNOAELoralDogToxValDB HPVIS
=39mg/kg bw/dayNOAELoralRatToxValDB HPVIS
>54mg/kg bw/dayNOAELoralMouseECHA
>58mg/kg bw/dayNOAELoralMouseECHA
=64mg/kg bw/dayNOAELoralRatECHA
>81mg/kg bw/dayNOAELoralRatECHA
=100mg/kg bw/dayNOAELoralRatToxValDB HPVIS
=150mg/kg bw/dayNOAELoralRatToxValDB HPVIS
>=218mg/kg bw/dayNOAELoralRatECHA
>=275mg/kg bw/dayNOAELoralRatECHA
=500mg/kg bw/dayNOAELoralMouseToxValDB HPVIS
>1000mg/kg bw/dayNOAELoralRatECHA
=1000mg/kg bw/dayNOAELoralRatToxValDB HPVIS
>=5000ppmNOAELoralRatECHA
>=543mg/m3NOECinhalationRatECHA
<500ppmNOELoralRatECHA
=1500ppmNOELoralRatECHA

Showing 30 of 30 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredOctadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate218-216-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate?

Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate has 30 NOAEL studies in the database. The lowest reported value is 3.6 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate?

Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate appears on 6 regulatory/inventory lists including IFRA Transparency, drinking_water; Europe; manufacturing; plastic_additive, Europe, and 3 more. Source: EPA CPDat.

Is Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate used in cosmetics?

Yes, Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is also indexed as a cosmetic ingredient under the name OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate have different safety status in cosmetics vs industrial chemicals?

Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is classified GHS CMR hazard (H317, H361, H411) in the chemicals database but is allowed in EU cosmetics.

Is Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate used outside industrial chemicals?

Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate also appears in cosmetics databases.