Good Cosmetic Ingredient NOAEL Data

OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE

CAS Number
2082-79-3
Function
Antioxidant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

5 study endpoints found for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL ca.34 mg/kg bw/day other dog oral REACH
NOAEL >=30 mg/kg bw/day oral rat oral REACH
NOAEL >64 mg/kg bw/day oral rat oral REACH
NOAEL >=58 mg/kg bw/day oral mouse oral REACH
NOAEL >=5000 mg/kg bw/day oral rat oral REACH

Expert Verdict

OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE is listed in the EU CosIng database with functions: Antioxidant It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted antioxidant needs-enrichment ifra_fragrance

Frequently Asked Questions

Is OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE safe in cosmetics?

OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE is listed in the EU CosIng database with functions: Antioxidant It is permitted in the EU without specific restrictions. The EU classifies OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE as "Permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.

Is OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE allowed in the EU?

OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE do in cosmetics?

OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 2082-79-3.

What is the NOAEL for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE?

The NOAEL (No Observed Adverse Effect Level) for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE is ca.34 mg/kg bw/day based on a oral study via other route in dog. A total of 5 study endpoints are available. Source: REACH.

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