What is the NOAEL for Diallyl disulfide?
Diallyl disulfide has 13 NOAEL studies in the database. The lowest reported value is 5HI47O6OA7 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Diallyl disulfide
Also known as: Disulfide, di-2-propenyl, Allyl disulphide, BRN 1699241, EINECS 218-548-6, FEMA No. 2028 (+6 more)
CAS 2179-57-9
Diallyl disulfide (CAS 2179-57-9) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Diallyl disulfide is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H315, H317, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Diallyl disulfide
CAS Number
2179-57-9
DTXSID
DTXSID9035206
Molecular Formula
C6H10S2
InChI Key
PFRGXCVKLLPLIP-UHFFFAOYSA-N
Monoisotopic Mass
146.022393
Synonyms
Disulfide, di-2-propenylAllyl disulphideBRN 1699241EINECS 218-548-6FEMA No. 20282-Propenyl disulfide2-Propenyl disulphideUNII-5HI47O6OA73,3'-disulfanediylbis(prop-1-ene)3,3'-dithiobis(prop-1-ene)3-(allyldisulfanyl)-1-propene
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5HI47O6OA7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5HI47O6OA7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5HI47O6OA7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5HI47O6OA7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =260 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 80 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 146 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =80 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =200 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIALLYLDISULFIDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Diallyl disulfide?
Diallyl disulfide appears on 5 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), active_ingredient; Pesticides, and 2 more. Source: EPA CPDat.
Is Diallyl disulfide used in cosmetics?
Yes, Diallyl disulfide is also indexed as a cosmetic ingredient under the name Diallyldisulphide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diallyl disulfide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Diallyl disulfide have different safety status in cosmetics vs industrial chemicals?
Diallyl disulfide is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H315, H317, H319).
Is Diallyl disulfide used outside industrial chemicals?
Diallyl disulfide also appears in cosmetics, pharmaceutical, cannabis databases.