Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Diallyldisulphide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 146 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 80 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Expert Verdict
Known contact allergen and principal cause of garlic-related allergic contact dermatitis. Can cause erythema, vesiculation, and eczema in sensitized individuals. Flammable with strong garlic odor. High sensitization potential makes justification in leave-on products difficult without HRIPT data at proposed use concentration.
Regulatory Flags
Frequently Asked Questions
Is Diallyldisulphide safe in cosmetics?
Known contact allergen and principal cause of garlic-related allergic contact dermatitis. Can cause erythema, vesiculation, and eczema in sensitized individuals. Flammable with strong garlic odor. High sensitization potential makes justification in leave-on products difficult without HRIPT data at proposed use concentration. The EU classifies Diallyldisulphide as "prohibited". Safety rating: POOR. 5 toxicological study endpoint(s) are available in our database.
Is Diallyldisulphide allowed in the EU?
Diallyldisulphide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diallyldisulphide do in cosmetics?
Diallyldisulphide functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2179-57-9.
What is the Margin of Safety for Diallyldisulphide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diallyldisulphide?
The NOAEL (No Observed Adverse Effect Level) for Diallyldisulphide is 146 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Diallyldisulphide compliance across multiple jurisdictions:
Related Ingredients
Is Diallyldisulphide in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diallyldisulphide in your formulation.