NOAEL Data Cosmetic Ingredient

(((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt

Also known as: Phosphonic acid, [[(phosphonomethyl)imino]bis[2,1-ethanediylnitrilobis(methylene)]]tetrakis-, sodium salt, Phosphonic acid, [[bis[2-[bis(phosphonomethyl)amino]ethyl]amino]methyl]-, sodium salt, Briquest 221, Briquest 543-25S, Briquest 543-45 (+15 more)

CAS 22042-96-2

(((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt (CAS 22042-96-2) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Sodium Diethylenetriamine Pentamethylene Phosphonate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

(((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt

CAS Number

22042-96-2

DTXSID

DTXSID2029321

Synonyms

Phosphonic acid, [[(phosphonomethyl)imino]bis[2,1-ethanediylnitrilobis(methylene)]]tetrakis-, sodium saltPhosphonic acid, [[bis[2-[bis(phosphonomethyl)amino]ethyl]amino]methyl]-, sodium saltBriquest 221Briquest 543-25SBriquest 543-45Briquest 543-45ASDETPMDequest 4066Diethylenetriaminepenta(methylenephosphonic acid) sodium saltMasquol P 550Phosphonic acid, [[(phosphonomethyl)imino]bis[2,1-ethanediylnitrilobis(methy lene)]]tetrakis-, sodium saltAcide [[(phosphonomethyl)imino]bis[(ethylenenitrilo)bis(methylene)]]tetrakisphosphonique, sel de sodium

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Chelating agentColor scavengerOxidizing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
fracking; water	NY Department of Conservation	CPCat
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 46 of 46 studies

Value	Unit	Endpoint	Route	Species	Source
18U8CZB0SP	UNII	FDA UNII substance identifier	-	-	openFDA substances
18U8CZB0SP	UNII	FDA UNII substance identifier	-	-	openFDA substances
18U8CZB0SP	UNII	FDA UNII substance identifier	-	-	openFDA substances
18U8CZB0SP	UNII	FDA UNII substance identifier	-	-	openFDA substances
96V6W55893	UNII	FDA UNII substance identifier	-	-	openFDA substances
96V6W55893	UNII	FDA UNII substance identifier	-	-	openFDA substances
96V6W55893	UNII	FDA UNII substance identifier	-	-	openFDA substances
96V6W55893	UNII	FDA UNII substance identifier	-	-	openFDA substances
E6DVO371LC	UNII	FDA UNII substance identifier	-	-	openFDA substances
E6DVO371LC	UNII	FDA UNII substance identifier	-	-	openFDA substances
E6DVO371LC	UNII	FDA UNII substance identifier	-	-	openFDA substances
E6DVO371LC	UNII	FDA UNII substance identifier	-	-	openFDA substances
EB6X2O1D2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
EB6X2O1D2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
EB6X2O1D2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
EB6X2O1D2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
IZ1NR8Y248	UNII	FDA UNII substance identifier	-	-	openFDA substances
IZ1NR8Y248	UNII	FDA UNII substance identifier	-	-	openFDA substances
IZ1NR8Y248	UNII	FDA UNII substance identifier	-	-	openFDA substances
IZ1NR8Y248	UNII	FDA UNII substance identifier	-	-	openFDA substances
OK9F2L7QZF	UNII	FDA UNII substance identifier	-	-	openFDA substances
OK9F2L7QZF	UNII	FDA UNII substance identifier	-	-	openFDA substances
OK9F2L7QZF	UNII	FDA UNII substance identifier	-	-	openFDA substances
OK9F2L7QZF	UNII	FDA UNII substance identifier	-	-	openFDA substances
OP813V0J36	UNII	FDA UNII substance identifier	-	-	openFDA substances
OP813V0J36	UNII	FDA UNII substance identifier	-	-	openFDA substances
OP813V0J36	UNII	FDA UNII substance identifier	-	-	openFDA substances
OP813V0J36	UNII	FDA UNII substance identifier	-	-	openFDA substances
P6WC2P6QUK	UNII	FDA UNII substance identifier	-	-	openFDA substances
P6WC2P6QUK	UNII	FDA UNII substance identifier	-	-	openFDA substances
P6WC2P6QUK	UNII	FDA UNII substance identifier	-	-	openFDA substances
P6WC2P6QUK	UNII	FDA UNII substance identifier	-	-	openFDA substances
U5G2UPY323	UNII	FDA UNII substance identifier	-	-	openFDA substances
U5G2UPY323	UNII	FDA UNII substance identifier	-	-	openFDA substances
U5G2UPY323	UNII	FDA UNII substance identifier	-	-	openFDA substances
U5G2UPY323	UNII	FDA UNII substance identifier	-	-	openFDA substances
X747VDM3JV	UNII	FDA UNII substance identifier	-	-	openFDA substances
X747VDM3JV	UNII	FDA UNII substance identifier	-	-	openFDA substances
X747VDM3JV	UNII	FDA UNII substance identifier	-	-	openFDA substances
X747VDM3JV	UNII	FDA UNII substance identifier	-	-	openFDA substances
=82.5	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=92.3	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=96	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HESS
>=151	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=195	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 46 of 46 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the NOAEL for (((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt?

(((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt has 46 NOAEL studies in the database. The lowest reported value is 18U8CZB0SP UNII. Source: openFDA substances.

What regulatory lists include (((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt?

(((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt appears on 2 regulatory/inventory lists including fracking; water, SCIL (9/2019). Source: EPA CPDat.

Is (((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt used in cosmetics?

Yes, (((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt is also indexed as a cosmetic ingredient under the name Sodium Diethylenetriamine Pentamethylene Phosphonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is (((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt used outside industrial chemicals?

(((Phosphonomethyl)imino)bis((ethylenenitrilo)bis(methylene)))tetrakisphosphonic acid, sodium salt also appears in cosmetics databases.