Also known as: Phosphonic acid, [[(phosphonomethyl)imino]bis[2,1-ethanediylnitrilobis(methylene)]]tetrakis-, sodium salt, Phosphonic acid, [[bis[2-[bis(phosphonomethyl)amino]ethyl]amino]methyl]-, sodium salt, Briquest 221, Briquest 543-25S, Briquest 543-45 (+15 more)
INCI: SODIUM DIETHYLENETRIAMINE PENTAMETHYLENE PHOSPHONATE
Sodium Diethylenetriamine Pentamethylene Phosphonate (CAS 22042-96-2) is a cosmetic cosmetic ingredient functioning as Chelating Agent. Reported NOAEL =82.5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 22042-96-2 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Diethylenetriamine Pentamethylene Phosphonate.
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3 study endpoints found for Sodium Diethylenetriamine Pentamethylene Phosphonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =82.5 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =92.3 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Expert safety assessment and concern-level summary for Sodium Diethylenetriamine Pentamethylene Phosphonate.
Public NOAEL study rows linked to Sodium Diethylenetriamine Pentamethylene Phosphonate by CAS number or substance name.
Sodium Diethylenetriamine Pentamethylene Phosphonate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Sodium Diethylenetriamine Pentamethylene Phosphonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Sodium Diethylenetriamine Pentamethylene Phosphonate functions as: Chelating Agent. It is classified as a cosmetic ingredient in our database. CAS number: 22042-96-2.
The NOAEL (No Observed Adverse Effect Level) for Sodium Diethylenetriamine Pentamethylene Phosphonate is =82.5 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
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