What is the NOAEL for Acetylpyrazine?
Acetylpyrazine has 5 NOAEL studies in the database. The lowest reported value is GR391IBU5C UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Acetylpyrazine
Also known as: EINECS 244-753-5, FEMA No. 3126, Ketone, methyl pyrazinyl, Methyl pyrazinyl ketone, NSC 72374 (+2 more)
CAS 22047-25-2
Acetylpyrazine (CAS 22047-25-2) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Acetylpyrazine
CAS Number
22047-25-2
DTXSID
DTXSID5047085
Molecular Formula
C6H6N2O
InChI Key
DBZAKQWXICEWNW-UHFFFAOYSA-N
Monoisotopic Mass
122.048013
Synonyms
EINECS 244-753-5FEMA No. 3126Ketone, methyl pyrazinylMethyl pyrazinyl ketoneNSC 723741-PyrazinylethanoneUNII-GR391IBU5C
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
14 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| GR391IBU5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GR391IBU5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GR391IBU5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GR391IBU5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8.2 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188662
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Acetylpyrazine?
Acetylpyrazine appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Acetylpyrazine used in cosmetics?
Yes, Acetylpyrazine is also indexed as a cosmetic ingredient under the name Methyl Pyrazinyl Ketone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetylpyrazine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Acetylpyrazine used outside industrial chemicals?
Acetylpyrazine also appears in cosmetics, pharmaceutical, cannabis databases.