Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Methyl Pyrazinyl Ketone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 8.2 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 8.2 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Classified as irritant - irritating to eyes, respiratory system, and skin (R36/37/38). Moisture-sensitive and air-sensitive. Also known as 2-acetylpyrazine; white to off-white crystalline powder; characteristic popcorn-like/roasted odor; melting point 76-78°C
Regulatory Flags
Frequently Asked Questions
Is Methyl Pyrazinyl Ketone safe in cosmetics?
Classified as irritant - irritating to eyes, respiratory system, and skin (R36/37/38). Moisture-sensitive and air-sensitive. Also known as 2-acetylpyrazine; white to off-white crystalline powder; characteristic popcorn-like/roasted odor; melting point 76-78°C The EU classifies Methyl Pyrazinyl Ketone as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Methyl Pyrazinyl Ketone allowed in the EU?
Methyl Pyrazinyl Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Pyrazinyl Ketone do in cosmetics?
Methyl Pyrazinyl Ketone functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 22047-25-2.
What is the Margin of Safety for Methyl Pyrazinyl Ketone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Pyrazinyl Ketone?
The NOAEL (No Observed Adverse Effect Level) for Methyl Pyrazinyl Ketone is 8.2 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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