Is Methyl Pyrazinyl Ketone safe in cosmetics?
Methyl Pyrazinyl Ketone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Methyl Pyrazinyl Ketone
Also known as: EINECS 244-753-5, FEMA No. 3126, Ketone, methyl pyrazinyl, NSC 72374, 1-Pyrazinylethanone (+1 more)
INCI: METHYL PYRAZINYL KETONE
Methyl Pyrazinyl Ketone (CAS 22047-25-2) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 22047-25-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-pyrazin-2-ylethanone
InChIKey
DBZAKQWXICEWNW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - also has FEMA GRAS status (FEMA 3126) for flavor use; no FDA cosmetic prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Pyrazinyl Ketone.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
784
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ACETYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ACETYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL PYRAZINYL KETONE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Pyrazinyl Ketone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
EINECS 244-753-5
FEMA No. 3126
Ketone, methyl pyrazinyl
NSC 72374
1-Pyrazinylethanone
UNII-GR391IBU5C
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188662
Frequently Asked Questions
Is Methyl Pyrazinyl Ketone allowed in the EU?
Methyl Pyrazinyl Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Pyrazinyl Ketone do in cosmetics?
Methyl Pyrazinyl Ketone functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 22047-25-2.
Is Methyl Pyrazinyl Ketone used outside cosmetics?
Methyl Pyrazinyl Ketone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyl Pyrazinyl Ketone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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