NOAEL Data Cosmetic Ingredient

4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate

Also known as: Quinolinium, 4-formyl-1-methyl-, 4-methylbenzenesulfonate (1:1), 4-Formyl-1-methylquinolinium-p-toluenesulfonate

CAS 223398-02-5

4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate (CAS 223398-02-5) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for 4-Formyl-1-Methylquinolinium-P-Toluenesulfonate →

SOURCE NOAEL studies
NOAEL studies
22
SOURCE Chemical inventory jurisdictions
Regulatory lists
1
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields
Name
4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate
CAS Number
223398-02-5
Molecular Formula
C11H10NO.C7H8O3S
InChI Key
GBWBUIOUJHJPOR-UHFFFAOYSA-M
Monoisotopic Mass
344.095654
Synonyms
Quinolinium, 4-formyl-1-methyl-, 4-methylbenzenesulfonate (1:1)4-Formyl-1-methylquinolinium-p-toluenesulfonate

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 22 of 22 studies
ValueUnitEndpointRouteSpeciesSource
100mg/kg bw-oral-Regulatory source
250mg/kg bw-oralratRegulatory source
1000mg/kg bw-oral-Regulatory source
>2000mg/kg bw-oralratRegulatory source
316mg/kg bw/dayLOAELoralratCOSMOS DB
=0.009mg/kg bw/dNOAELoralratSCCS Opinion
=0.0297mg/kg bw/dNOAELoralratSCCS Opinion
100mg/kg bw/dayNOAELoralratCOSMOS DB
=100mg/kg bwNOAELoral-SCCS Opinion
=100mg/kg bw/dNOAELoralratSCCS Opinion
=250mg/kg bw/dayNOAELoral-SCCS Opinion
=250mg/kg bwNOAELoralratSCCS Opinion
1000mg/kg bw/dayNOAELoralratCOSMOS DB
=1000mg/kg bwNOAELoral-SCCS Opinion
>2000mg/kg bwNOAELoralratSCCS Opinion
=0.009mg/kg bw/ddermal absorptionoralratRegulatory source
=0.0297mg/kg bw/ddermal absorptionoralratRegulatory source
=100mg/kg bw/ddermal absorptionoralratRegulatory source
100mg/kg bwdermal absorptiondermalrabbitRegulatory source
250mg/kg bw/daygenotoxicityoral-Regulatory source
1000mg/kg bwirritationoralratRegulatory source
>2000mg/kg bwirritationoralratRegulatory source

Showing 22 of 22 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0923/0513 December 2005The SCCP is of the opinion that the information submitted is insufficient to assess the safe use of the substance.-Information submitted insufficient to assess safe use; further information required before any consideration.
SCCS/1435/112011-12-14Based on the data provided, Quinolinium, 4-formyl-1-methyl-, salt with 4-methylbenzenesulfonic acid (1:1) does not pose a risk to the health of the consumer when used as an oxidative hair dye (used in the absence or presence of hydrogen peroxide) with a maximum on-head concentration of 2.5%.2.5%Mutagenic in vitro (gene mutations in bacteria, chromosome aberrations in mammalian cells); in vitro positives not confirmed in vivo (negative micronucleus and UDS tests), so considered to have no in vivo genotoxic potential. Earlier SCCP/0923/05 had found data insufficient.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
2.5%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate?

4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate has 22 NOAEL studies in the database. The lowest reported value is 0.009 mg/kg bw/d via oral in rat. Source: SCCS Opinion.

What regulatory lists include 4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate?

4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate used in cosmetics?

Yes, 4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate is also indexed as a cosmetic ingredient under the name 4-Formyl-1-Methylquinolinium-P-Toluenesulfonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate used outside industrial chemicals?

4-Formyl-1-methylquinolin-1-ium 4-methylbenzene-1-sulfonate also appears in cosmetics databases.